ArticleBiophysical journal2010
Lateral diffusion of membrane proteins: consequences of hydrophobic mismatch and lipid composition.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
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- Membrane Molecular Species Remodeling as a Signature of ω-3 Fatty Acid Action in Cultured Neural Cells.ASN neuro · 2026Article
- Energetics of the Transmembrane Peptide Sorting by Hydrophobic Mismatch.The journal of physical chemistry letters · 2024Article
- Toward atomistic models of intact severe acute respiratory syndrome coronavirus 2 via Martini coarse-grained molecular dynamics simulations.Quantitative biology (Beijing, China) · 2023Article
- Super-resolving microscopy reveals the localizations and movement dynamics of stressosome proteins in Listeria monocytogenes.Communications biology · 2023Article
- High-Resolution Magic Angle Spinning NMR of KcsA in Liposomes: The Highly Mobile C-Terminus.Biomolecules · 2022Article
- VAMP2 and synaptotagmin mobility in chromaffin granule membranes: implications for regulated exocytosis.Molecular biology of the cell · 2022Article
- Fluorescence microscopy imaging of a neurotransmitter receptor and its cell membrane lipid milieu.Frontiers in molecular biosciences · 2022Review
- Assessing the use of ellipsoidal microparticles for determining lipid membrane viscosity.Biophysical journal · 2021Article
- A Systematic Approach: Molecular Dynamics Study and Parametrisation of Gemini Type Cationic Surfactants.International journal of molecular sciences · 2021Article
- The membrane transporter lactose permease increases lipid bilayer bending rigidity.Biophysical journal · 2021Article
- A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy.Molecular biology of the cell · 2021Article
- Constructing ion channels from water-soluble α-helical barrels.Nature chemistry · 2021Article
- Heterodimer Formation of the Homodimeric ABC Transporter OpuA.International journal of molecular sciences · 2021Article
- Article
- Polyunsaturated fatty acids promoteBiology open · 2019Article
- Genetically Compromising Phospholipid Metabolism Limits Candida albicans' Virulence.Mycopathologia · 2019Article
- Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion.Science (New York, N.Y.) · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Biological membranes are composed of a large number lipid species differing in hydrophobic length, degree of saturation, and charge and size of the headgroup. We now present data on the effect of hydrocarbon chain length of the lipids and headgroup composition on the lateral mobility of the proteins in model membranes. The trimeric glutamate transporter (GltT) and the monomeric lactose transporter (LacY) were reconstituted in giant unilamellar vesicles composed of unsaturated phosphocholine lipids of varying acyl chain length (14-22 carbon atoms) and various ratios of DOPE/DOPG/DOPC lipids. The lateral mobility of the proteins and of a fluorescent lipid analog was determined as a function of the hydrophobic thickness of the bilayer (h) and lipid composition, using fluorescence correlation spectroscopy. The diffusion coefficient of LacY decreased with increasing thickness of the bilayer, in accordance with the continuum hydrodynamic model of Saffman-Delbrück. For GltT, the mobility had its maximum at diC18:1 PC, which is close to the hydrophobic thickness of the bilayer in vivo. The lateral mobility decreased linearly with the concentration of DOPE but was not affected by the fraction of anionic lipids from DOPG. The addition of DOPG and DOPE did not affect the activity of GltT. We conclude that the hydrophobic thickness of the bilayer is a major determinant of molecule diffusion in membranes, but protein-specific properties may lead to deviations from the Saffman-Delbrück model.
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