ArticleBiophysical journal2010
Localization microscopy reveals expression-dependent parameters of chromatin nanostructure.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast.Journal of visualized experiments : JoVE · 2026Article
- Chemical-induced phase transition and global conformational reorganization of chromatin.Nature communications · 2023Article
- Review
- Inter-nucleosomal potentials from nucleosomal positioning data.The European physical journal. E, Soft matter · 2022Article
- Superstructure Detection in Nucleosome Distribution Shows Common Pattern within a Chromosome and within the Genome.Life (Basel, Switzerland) · 2022Article
- Self-organization of whole-gene expression through coordinated chromatin structural transition.Biophysics reviews · 2021Review
- Review
- Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation.PloS one · 2021Article
- Super-resolution Microscopy with Single Molecules in Biology and Beyond-Essentials, Current Trends, and Future Challenges.Journal of the American Chemical Society · 2020Review
- Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223.Cancers · 2019Article
- Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo.Nucleic acids research · 2019Article
- A guide to visualizing the spatial epigenome with super-resolution microscopy.The FEBS journal · 2019Review
- Chromatin condensation fluctuations rather than steady-state predict chromatin accessibility.Nucleic acids research · 2019Article
- High-resolution visualization of H3 variants during replication reveals their controlled recycling.Nature communications · 2018Article
- Using Persistent Homology as a New Approach for Super-Resolution Localization Microscopy Data Analysis and Classification of γH2AX Foci/Clusters.International journal of molecular sciences · 2018Article
- Localization Microscopy Analyses of MRE11 Clusters in 3D-Conserved Cell Nuclei of Different Cell Lines.Cancers · 2018Article
- Challenges for Super-Resolution Localization Microscopy and Biomolecular Fluorescent Nano-Probing in Cancer Research.International journal of molecular sciences · 2017Article
- Super-Resolution Localization Microscopy of γ-H2AX and Heterochromatin after Folate Deficiency.International journal of molecular sciences · 2017Article
- Stochastic fluorescence switching of nucleic acids under visible light illumination.Optics express · 2017Article
- Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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11 authors.
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Abstract
A combined approach of 2D high-resolution localization light microscopy and statistical methods is presented to infer structural features and density fluctuations at the nuclear nanoscale. Hallmarks of nuclear nanostructure are found on the scale below 100 nm for both human fibroblast and HeLa cells. Mechanical measures were extracted as a quantitative tool from the histone density fluctuations inside the cell to obtain structural fluctuations on the scale of several micrometers. Results show that different mechanisms of expression of the same nuclear protein type lead to significantly different patterns on the nanoscale and to pronounced differences in the detected compressibility of chromatin. The observed fluctuations, including the experimental evidence for dynamic looping, are consistent with a recently proposed chromatin model.
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