ArticleBMC gastroenterology2010
Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China.
Article in BMC gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiology and clinical course of primary biliary cholangitis in the Asia-Pacific region: a systematic review and meta-analysis.Hepatology international · 2019Pooled it
- Guideline
- Geoepidemiology of Primary Biliary Cholangitis: Lessons from Switzerland.Clinical reviews in allergy & immunology · 2018Trial
- A multifaceted analysis of OTUD5 integrated MAVS in innate immunity of Primary Biliary Cholangitis.PloS one · 2026Article
- A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers.Hepatology communications · 2025Article
- Recurrent Hypoglycemic Coma Episodes Associated With Primary Biliary Cirrhosis.JCEM case reports · 2025Article
- Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive.Clinical and molecular hepatology · 2025Article
- Article
- Epidemiology and distribution of 207 rare diseases in China: A systematic literature review.Intractable & rare diseases research · 2024Review
- ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han.Hepatology international · 2024Article
- Article
- Clinicopathological features of 11 cases of chronic hepatitis B infection complicated with primary biliary cholangitis.World journal of hepatology · 2023Article
- [Roles of the CXCR1/CXCL8 axis in abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis.Hepatology international · 2022Article
- Characteristics of peripheral blood Gamma-glutamyl transferase in different liver diseases.Medicine · 2022Article
- Clinical characteristics and prognosis of amyotrophic lateral sclerosis with autoimmune diseases.PloS one · 2022Article
- The clinical and laboratory features associated with cancer in patients with primary biliary cholangitis: a longitudinal survey-based study.Clinical rheumatology · 2021Article
- PBC: No Longer a Western Disease?Clinical liver disease · 2020Review
- Role of cell autophagy in the generation of IgM and hepatic fibrosis in primary biliary cholangitis.Clinical rheumatology · 2020Article
- Epidemiology and clinical course of primary biliary cholangitis in Eastern Slovakia.International journal of public health · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of anti-mitocondrial autoantibodies (AMA) which has an essential role also for diagnosis. In addition, also some anti-nuclear antibodies (ANA) have been shown to be highly specific PBC. The purpose of this study was to assess the prevalence of PBC among the adults referring hospital for annual health check-up in Southern China by screening sera for PBC-specific autoantibodies.
methodsAMA and ANA were screened in 8,126 adults (mean age 44 ± 15 years, 48% females) by indirect immunofluorenscence (IIF). Positive sera were tested by ELISA/immunoblotting for AMA-M2, anti-sp100 and anti-gp210. A diagnosis of PBC was re-assessed six months after the initial testing.
resultsOut of 8,126 individuals 35 were positive for AMA and 79 positive for ANA. Nineteen, 4, and 3 of the subjects positive for AMA and/or ANA showed reactivity for AMA-M2, anti-sp100 or gp210, respectively, further tested with ELISA/immunoblotting. Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices. One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.
conclusionsWe found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.
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