ArticleFree radical research2010
Ascorbic acid prevents increased endothelial permeability caused by oxidized low density lipoprotein.
Article in Free radical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of cooking using multi-ply cookware on absorption of potassium and vitamins: a randomized double-blind placebo control study.International journal of food sciences and nutrition · 2012Trial
- Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity.Antioxidants (Basel, Switzerland) · 2024Article
- Gender Differences in Plasma Vitamin C Concentrations and Cognitive Function: A Pilot Cross-Sectional Study in Healthy Adults.Current developments in nutrition · 2020Article
- Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress.Current topics in membranes · 2020Review
- The Contribution of Plasma and Brain Vitamin C on Age and Gender-Related Cognitive Differences: A Mini-Review of the Literature.Frontiers in integrative neuroscience · 2020Review
- Article
- Vitamin C, Aging and Alzheimer's Disease.Nutrients · 2017Review
- Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton.American journal of physiology. Cell physiology · 2016Article
- Ascorbic acid repletion: A possible therapy for diabetic macular edema?Free radical biology & medicine · 2016Review
- Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability.Molecular and cellular biochemistry · 2016Article
- Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women.The American journal of clinical nutrition · 2015Observational
- Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor.Biomicrofluidics · 2015Article
- Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin.The Journal of biological chemistry · 2015Article
- The role of vitamin supplementation in the prevention of cardiovascular disease events.Clinical cardiology · 2014Review
- Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy.Journal of translational medicine · 2014Review
- Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.Behavioural brain research · 2014Article
- Review
- Role of vitamin C in the function of the vascular endothelium.Antioxidants & redox signaling · 2013Review
- The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention.American journal of Alzheimer's disease and other dementias · 2013Review
- Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?Journal of translational medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Abstract Mildly oxidized low density lipoprotein (mLDL) acutely increases the permeability of the vascular endothelium to molecules that would not otherwise cross the barrier. This study has shown that ascorbic acid tightens the permeability barrier in the endothelial barrier in cells, so this work tested whether it might prevent the increase in endothelial permeability due to mLDL. Treatment of EA.hy926 endothelial cells with mLDL decreased intracellular GSH and activated the cells to further oxidize the mLDL. mLDL also increased endothelial permeability over 2 h to both inulin and ascorbate in cells cultured on semi-permeable filters. This effect was blocked by microtubule and microfilament inhibitors, but not by chelation of intracellular calcium. Intracellular ascorbate both prevented and reversed the mLDL-induced increase in endothelial permeability, an effect mimicked by other cell-penetrant antioxidants. These results suggest a role for endothelial cell ascorbate in ameliorating an important facet of endothelial dysfunction caused by mLDL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.