Trial reportSleep2010
Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT.
Trial report in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.British journal of pharmacology · 2012Trial
- Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?Current oncology reports · 2025Review
- Stable interindividual differences in modafinil's effect on vigilance during sleep deprivation.Frontiers in pharmacology · 2025Article
- Review
- Effects of Modafinil on Sleep Pattern during Methamphetamine Withdrawal: A Double-blind Randomized Controlled Trial.Addiction & health · 2019Article
- Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017Review
- Sleep and plasticity in schizophrenia.Current topics in behavioral neurosciences · 2015Review
- Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- About sleep's role in memory.Physiological reviews · 2013Review
- Predicting Risk in Space: Genetic Markers for Differential Vulnerability to Sleep Restriction.Acta astronautica · 2012Article
- Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys.Experimental and clinical psychopharmacology · 2012Article
- Article
- Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms.Frontiers in neurology · 2012Article
- Genetics of Sleep Timing, Duration and Homeostasis in Humans.Sleep medicine clinics · 2011Article
- Article
- Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Chronobiology internationalArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesModafinil may promote wakefulness by increasing cerebral dopaminergic neurotransmission, which importantly depends on activity of catechol-O-methyltransferase (COMT) in prefrontal cortex. The effects of modafinil on sleep homeostasis in humans are unknown. Employing a novel sleep-pharmacogenetic approach, we investigated the interaction of modafinil with sleep deprivation to study dopaminergic mechanisms of sleep homeostasis.
designPlacebo-controlled, double-blind, randomized crossover study.
settingSleep laboratory in temporal isolation unit.
participants22 healthy young men (23.4 +/- 0.5 years) prospectively enrolled based on genotype of the functional Val158Met polymorphism of COMT(10 Val/Val and 12 Met/Met homozygotes).
interventions2 x 100 mg modafinil and placebo administered at 11 and 23 hours during 40 hours prolonged wakefulness. MEASUREMENTS AND
resultsSubjective sleepiness and EEG markers of sleep homeostasis in wakefulness and sleep were equally affected by sleep deprivation in Val/Val and Met/Met allele carriers (placebo condition). Modafinil attenuated the evolution of sleepiness and EEG 5-8 Hz activity during sleep deprivation in both genotypes. In contrast to caffeine, modafinil did not reduce EEG slow wave activity (0.75-4.5 Hz) in recovery sleep, yet specifically increased 3.0-6.75 Hz and > 16.75 Hz activity in NREM sleep in the Val/Val genotype of COMT.
conclusionsThe Val158Met polymorphism of COMT modulates the effects of modafinil on the NREM sleep EEG in recovery sleep after prolonged wakefulness. The sleep EEG changes induced by modafinil markedly differ from those of caffeine, showing that pharmacological interference with dopaminergic and adenosinergic neurotransmission during sleep deprivation differently affects sleep homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.