Evidence map›Paper›PMID 20814827›Full record

ReviewJournal of inherited metabolic disease2011

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.

Henk J Blom, Yvo Smulders

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of inherited metabolic disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03674333 (Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias), which is not on this map. Cited by 172 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03674333 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias

TypeinterventionalSponsorShaheed Zulfiqar Ali Bhutto Medical UniversityRan2018 to 2019Enrolled68ConditionsDyslipidemiasArmsFolic Acid, Placebo
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  5. MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015
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  10. Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Henk J BlomMetabolic Unit, Department of Clinical Chemistry, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Centre, Amsterdam, The Netherlands. h.blom@vumc.nl
Yvo Smulders

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This overview addresses homocysteine and folate metabolism. Its functions and complexity are described, leading to explanations why disturbed homocysteine and folate metabolism is implicated in many different diseases, including congenital birth defects like congenital heart disease, cleft lip and palate, late pregnancy complications, different kinds of neurodegenerative and psychiatric diseases, osteoporosis and cancer. In addition, the inborn errors leading to hyperhomocysteinemia and homocystinuria are described. These extreme human hyperhomocysteinemia models provide knowledge about which part of the homocysteine and folate pathways are linked to which disease. For example, the very high risk for arterial and venous occlusive disease in patients with severe hyperhomocysteinemia irrespective of the location of the defect in remethylation or transsulphuration indicates that homocysteine itself or one of its "direct" derivatives is considered toxic for the cardiovascular system. Finally, common diseases associated with elevated homocysteine are discussed with the focus on cardiovascular disease and neural tube defects.

Indexed as

Cardiovascular DiseasesFemaleFolic AcidHomocysteineHumansModels, BiologicalNeural Tube DefectsPregnancyRisk FactorsFolic AcidHomocysteine

Identifiers

PMID20814827
PMCPMC3026708

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.