ArticlePsychopharmacology2011
Effects of acute pramipexole on preference for gambling-like schedules of reinforcement in rats.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks.Translational psychiatry · 2024Article
- Choice between food and cocaine or fentanyl reinforcers under fixed and variable schedules in female and male rhesus monkeys.Psychopharmacology · 2023Article
- Environmental Uncertainty and Substance Use Disorders: A Behavior Analytic Perspective.Policy insights from the behavioral and brain sciences · 2023Article
- Choice between food and cocaine reinforcers under fixed and variable schedules in female and male rhesus monkeys.Experimental and clinical psychopharmacology · 2023Article
- Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.Clocks & sleep · 2021Article
- Unpredictability as a modulator of drug self-administration: Relevance for substance-use disorders.Behavioural processes · 2020Review
- Can Slot-Machine Reward Schedules Induce Gambling Addiction in Rats?Journal of gambling studies · 2019Article
- Dopaminergic influences on risk preferences of Parkinson's disease patients.Cognitive, affective & behavioral neuroscience · 2019Article
- Uncertainty processing in bees exposed to free choices: Lessons from vertebrates.Psychonomic bulletin & review · 2018Review
- Impulse control disorders in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- The neurobiology of impulse control disorders in Parkinson's disease: from neurotransmitters to neural networks.Cell and tissue research · 2018Review
- Choice between variable and fixed cocaine injections in male rhesus monkeys.Psychopharmacology · 2017Article
- Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats.Progress in neuro-psychopharmacology & biological psychiatry · 2017Article
- Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.Neuropharmacology · 2017Article
- Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease.Frontiers in behavioral neuroscience · 2017Article
- Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy.Neuropharmacology · 2016Article
- The benefits of pramipexole selection in the treatment of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Review
- A new approach to assess gambling-like behavior in laboratory rats: using intracranial self-stimulation as a positive reinforcer.Frontiers in behavioral neuroscience · 2014Article
- Pramipexole-induced disruption of behavioral processes fundamental to intertemporal choice.Journal of the experimental analysis of behavior · 2013Article
- Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior.Psychopharmacology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationalePramipexole and other direct dopamine agonist medications have been implicated in the development of impulsive behavior such as pathological gambling among those taking the drug to control symptoms of Parkinson's disease or restless leg syndrome. Few laboratory studies examining pramipexole's effects on gambling-like behavior have been conducted.
objectivesThe present study used a rodent model approximating some aspects of human gambling to examine within-subject effects of acute pramipexole (0.03, 0.1, 0.18, and 0.3 mg/kg) on rat's choices to earn food reinforcement by completing variable-ratio (VR; i.e., gambling-like) or fixed-ratio (FR) response requirements.
resultsIn a condition in which the VR alternative was rarely selected, all but the lowest dose of pramipexole significantly increased choice of the VR alternative (an average of 15% above saline). The same doses did not affect choice significantly in a control condition designed to evaluate the involvement of nonspecific drug effects. Pramipexole increased latencies to initiate trials (+9.12 s) and to begin response runs on forced-choice trials (VR = +0.21 s; FR = +0.88 s), but did not affect measures of response perseveration (conditional probabilities of "staying").
conclusionsThe findings are consistent with clinical reports linking pramipexole to the expression of increased gambling in humans. Results are discussed in the context of neurobehavioral evidence suggesting that dopamine agonists increase sensitivity to reward delay and disrupt appropriate feedback from negative outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.