ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2010
Opuntia humifusa partitioned extracts inhibit the growth of U87MG human glioblastoma cells.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
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- Beneficial Effects ofAntioxidants (Basel, Switzerland) · 2023Review
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- Ferocactus herrerae Fruits: Nutritional Significance, Phytochemical Profiling, and Biological Potentials.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Article
- Comparative study betweenHeliyon · 2021Article
- Therapeutic potential of natural products in glioblastoma treatment: targeting key glioblastoma signaling pathways and epigenetic alterations.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Review
- Gene-targeted molecular phylogeny, phytochemical profiling, and antioxidant activity of nine species belonging to family Cactaceae.Saudi journal of biological sciences · 2020Article
- Functional Teas from the Stems of Penthorum chinense Pursh.: Phenolic Constituents, Antioxidant and Hepatoprotective Activity.Plant foods for human nutrition (Dordrecht, Netherlands) · 2019Article
- Chemical composition, antioxidant, anti-inflammatory, and cytotoxic activities of Opuntia stricta cladodes.PloS one · 2019Article
- Natural products: a hope for glioblastoma patients.Oncotarget · 2018Review
- Review
- Extracts of Opuntia humifusa Fruits Inhibit the Growth of AGS Human Gastric Adenocarcinoma Cells.Preventive nutrition and food science · 2016Article
- The biological activities and chemical composition of Pereskia species (Cactaceae)--a review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opuntia humifusa, a member of the Cactaceae family widely distributed in the southern regions of the Korean peninsula, has potential bioactive functions and medicinal benefits. In the present study, we investigated the effect of hexane, ethyl acetate extracts and water partitioned fraction of O. humifusa on proliferation, G1 arrest and apoptosis in U87MG human glioblastoma cells. Glioblastoma cellular proliferation was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and the effects of O. humifusa partitioned extracts on cell cycle and apoptosis were analyzed by flow cytometry. Our results revealed that when U87MG cells were treated with hexane extracts and water partitioned fraction of O. humifusa, the number of viable cells decreased in a concentration-dependent manner. In addition, water partitioned fractions of O. humifusa induced G1 arrest and non-apoptotic cell death as well as significant increases in ROS production in U87MG cells. In conclusion, water partitioned fractions of O. humifusa induce G1 arrest and inhibit U87MG human glioblastoma cell proliferation.
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