ArticleEuropean journal of nuclear medicine and molecular imaging2010
Detection and quantification of remote microglial activation in rodent models of focal ischaemia using the TSPO radioligand CLINDE.
Article in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 26 citations in OpenAlex.
- Out of the core: the impact of focal ischemia in regions beyond the penumbra.Frontiers in cellular neuroscience · 2024Review
- A pilot [Brain, behavior, & immunity - health · 2021Article
- New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery.Frontiers in cellular neuroscience · 2021Review
- PET imaging of neuroinflammation in neurological disorders.The Lancet. Neurology · 2020Review
- Inflammatory Responses in the Secondary Thalamic Injury After Cortical Ischemic Stroke.Frontiers in neurology · 2020Review
- Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness.Scientific reports · 2018Article
- Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [Schizophrenia research · 2018Article
- Changes in Binding of [(123)I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury.Neuromolecular medicine · 2016Article
- Comparison of in vivo binding properties of the 18-kDa translocator protein (TSPO) ligands [(18)F]PBR102 and [ (18)F]PBR111 in a model of excitotoxin-induced neuroinflammation.European journal of nuclear medicine and molecular imaging · 2015Article
- The 18 kDa translocator protein, microglia and neuroinflammation.Brain pathology (Zurich, Switzerland) · 2014Review
- A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation.Journal of neuroscience methods · 2014Article
- Evaluation of [¹²³I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation.European journal of nuclear medicine and molecular imaging · 2011Article
- The application of permanent middle cerebral artery ligation in the mouse.Journal of visualized experiments : JoVE · 2011Article
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNeuroinflammation is involved in stroke pathophysiology and might be imaged using radioligands targeting the 18 kDa translocator protein (TSPO).
methodsWe studied microglial reaction in brain areas remote from the primary lesion site in two rodent models of focal cerebral ischaemia (permanent or transient) using [125I]-CLINDE, a promising TSPO single photon emission computed tomography radioligand.
resultsIn a mouse model of permanent middle cerebral artery occlusion (MCAO), ex vivo autoradiographic studies demonstrated, besides in the ischaemic territory, accumulation of [125I]-CLINDE in the ipsilateral thalamus with a binding that progressed up to 3 weeks after MCAO. [125I]-CLINDE binding markedly decreased in animals pre-injected with either unlabelled CLINDE or PK11195, while no change was observed with flumazenil pre-treatment, demonstrating TSPO specificity. In rats subjected to transient MCAO, [125I]-CLINDE binding in the ipsilateral thalamus and substantia nigra pars reticulata (SNr) was significantly higher than that in contralateral tissue. Moreover, [125I]-CLINDE binding in the thalamus and SNr was quantitatively correlated to the ischaemic volume assessed by MRI in the cortex and striatum, respectively.
conclusionClinical consequences of secondary neuronal degeneration in stroke might be better treated thanks to the discrimination of neuronal processes using in vivo molecular imaging and potent TSPO radioligands like CLINDE to guide therapeutic interventions.
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