Evidence map›Paper›PMID 20814670›Full record

ArticleCalcified tissue international2010

Evaluation of compressive strength index of the femoral neck in Caucasians and chinese.

Na Yu, Yong-Jun Liu, Yufang Pei, Lei Zhang, Shufeng Lei, Niraj R Kothari, Ding-You Li, Christopher J Papasian, James Hamilton, Ji-Qun Cai and 1 more

Abstract readComparative Study
In one paragraph

Article in Calcified tissue international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

  1. C-reactive protein, bone strength, and nine-year fracture risk: data from the Study of Women's Health Across the Nation (SWAN).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Trial
  2. Article
  3. Article
  4. Article
  5. Comparison of femoral neck geometric parameters between Chinese and Japanese females.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  6. [Predictive effect of femoral neck strength composite indexes on femoral head collapse in non-traumatic osteonecrosis of femoral head].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Article
  7. The positive association of total protein intake with femoral neck strength (KNHANES IV).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  8. Association between obesity and femoral neck strength according to age, sex, and fat distribution.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  9. Adult bone strength of children from single-parent families: the Midlife in the United States Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  10. Low skeletal muscle mass associates with low femoral neck strength, especially in older Korean women: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  11. Insulin resistance and bone strength: findings from the study of midlife in the United States.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014
    Article
  12. Physical activity as determinant of femoral neck strength relative to load in adult women: findings from the hip strength across the menopause transition study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Article
  13. Review
  14. Article
  15. Article
  16. Trajectories of femoral neck strength in relation to the final menstrual period in a multi-ethnic cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Article
  17. Article
  18. Review
  19. Epidemiology and structural basis of racial differences in fragility fractures in Chinese and Caucasians.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Na YuDepartment of Pharmaceutical Toxicology, China Medical University, Shenyang, People's Republic of China.
Yong-Jun Liu
Yufang Pei
Lei Zhang
Shufeng Lei
Niraj R Kothari
Ding-You Li
Christopher J Papasian
James Hamilton
Ji-Qun Cai
Hong-Wen Deng
University of Missouri–Kansas City · USChildren's Mercy Hospital · USHunan Normal University · CNShenyang Pharmaceutical University · CN

Funding

Proteome-wide Expression Study of Osteogenic CellsP50AR055081 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2012
$5.0M
ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSR01AR050496 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2004 to 2013
$3.8M
Identification of Proteins Important for Male OsteoporosisR01AR057049 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2013
$2.4M
Genomic search for bone mass QTLsR01AG026564 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2010
$2.3M
Proteomics Study of Peripheral Blood Monocytes on OsteroporsisR21AG027110 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2006 to 2007
$367k
Alcohol Dependence Genetics in a Large Chinese PedigreeR21AA015973 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2007 to 2008
$345k
NIAAA NIH HHS R21 AA015973NIAMS NIH HHS P50 AR055081NIAMS NIH HHS R01 AR050496NIAMS NIH HHS R01 AR057049NIA NIH HHS R01 AG026564NIA NIH HHS R21 AG027110
6 · The paper itself

Abstract

Compressive strength index (CSI) of the femoral neck is a parameter that integrates the information of bone mineral density (BMD), femoral neck width (FNW), and body weight. CSI is considered to have the potential to improve the performance of assessment for hip fracture risk. However, studies on CSI have been rare. In particular, few studies have evaluated the performance of CSI, in comparison with BMD, FNW, and bending geometry, for assessment of hip fracture risk. We studied two large populations, including 1683 unrelated U.S. Caucasians and 2758 unrelated Chinese adults. For all the study subjects, CSI, femoral neck BMD (FN_BMD), FNW, and bending geometry (section modulus [Z]) of the samples were obtained from dual-energy X-ray absorptiometry scans. We investigated the age-related trends of these bone phenotypes and potential sex and ethnic differences. We further evaluated the performance of these four phenotypes for assessment of hip fracture risk by logistic regression models. Chinese had significantly lower FN_BMD, FNW, and Z, but higher CSI than sex-matched Caucasians. Logistic regression analysis showed that higher CSI was significantly associated with lower risk of hip fracture, and the significance remained after adjusting for covariates of age, sex, and height. Each standard deviation (SD) increment in CSI was associated with odds ratios of 0.765 (95% confidence interval, 0.634, 0.992) and 0.724 (95% confidence interval, 0.569, 0.921) for hip fracture risk in Caucasians and Chinese, respectively. The higher CSI in Chinese may partially help explain the lower incidence of hip fractures in this population compared to Caucasians. Further studies in larger cohorts and/or longitudinal observations are necessary to confirm our findings.

Indexed as

Asian PeopleWhite PeopleBody Mass IndexBone DensityCompressive StrengthFemaleFemur NeckHip FracturesHumansLogistic ModelsMaleMiddle AgedRisk Assessment

Identifiers

PMID20814670
PMCPMC4176885
OpenAlexW2010740310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.