ReviewAnalytical and bioanalytical chemistry2011
Analysis and characterization of heparin impurities.
Review in Analytical and bioanalytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Dynamics of Heparin Translocations Through Solid-State Nanopores.Electrophoresis · 2026Article
- Biocompatible Macroion/Growth Factor Assemblies for Medical Applications.Biomolecules · 2023Review
- Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State.ACS central science · 2023Article
- Utilizing theInternational journal of molecular sciences · 2023Article
- A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application.Current issues in molecular biology · 2022Review
- Nuclear Magnetic Resonance Methods in Structural Characterization of Glycosaminoglycans.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Recent developments in sensing of oversulfated chondroitin sulfate in heparin. A review.Journal of food and drug analysis · 2021Review
- Techniques for Detection of Clinical Used Heparins.International journal of analytical chemistry · 2021Review
- Quality Control of Heparin Injections: Comparison of Four Established Methods.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Review
- Glycosaminoglycans from Co-Products of «Biological procedures online · 2020Article
- Tools for the Quality Control of Pharmaceutical Heparin.Medicina (Kaunas, Lithuania) · 2019Review
- Low-molecular-weight sulfonated chitosan as template for anticoagulant nanoparticles.International journal of nanomedicine · 2018Article
- Article
- Recent Liquid Chromatographic Approaches and Developments for the Separation and Purification of Carbohydrates.Analytical methods : advancing methods and applications · 2017Article
- Analysis of glycosaminoglycan-derived, precolumn, 2-aminoacridone-labeled disaccharides with LC-fluorescence and LC-MS detection.Nature protocols · 2014Article
- Method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry.Analytical chemistry · 2014Article
- Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase.The FEBS journal · 2013Article
- Electrophoresis for the analysis of heparin purity and quality.Electrophoresis · 2012Review
- Linear polyalkylamines as fingerprinting agents in capillary electrophoresis of low-molecular-weight heparins and glycosaminoglycans.Electrophoresis · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review discusses recent developments in analytical methods available for the sensitive separation, detection and structural characterization of heparin contaminants. The adulteration of raw heparin with oversulfated chondroitin sulfate (OSCS) in 2007-2008 spawned a global crisis resulting in extensive revisions to the pharmacopeia monographs on heparin and prompting the FDA to recommend the development of additional physicochemical methods for the analysis of heparin purity. The analytical chemistry community quickly responded to this challenge, developing a wide variety of innovative approaches, several of which are reported in this special issue. This review provides an overview of methods of heparin isolation and digestion, discusses known heparin contaminants, including OSCS, and summarizes recent publications on heparin impurity analysis using sensors, near-IR, Raman, and NMR spectroscopy, as well as electrophoretic and chromatographic separations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.