ArticleInternational journal of Ayurveda research2010
Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia.
Article in International journal of Ayurveda research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Co-administration ofCurrent topics in medicinal chemistry · 2022Article
- Increased insulin and GLUT2 gene expression and elevated glucokinase activity in β-like cells of islets of langerhans differentiated from human haematopoietic stem cells on treatment with Costus igneus leaf extract.Molecular biology reports · 2021Article
- Article
- A review on Insulin plant (Costus igneus Nak).Pharmacognosy reviews · 2014Review
- Effect of insulin plant leaves on dexamethasone-induced hyperglycemia.International journal of Ayurveda research · 2011Article
- Insulin Plant (Pharmacognosy researchArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledCostus igneus, commonly known as insulin plant in India, belongs to the family Costaceae. Consumption of the leaves are believed to lower blood glucose levels, and diabetics who consumed the leaves of this plant did report a fall in their blood glucose levels.
objectivesThe present study was planned to evaluate the effect of the leaves of Costus igeus on dexamethasone-induced hyperglycemia in male Wistar rats. Four groups of male Wistar rats (n= 6) were treated with 10 mg/kg/day of dexamethasone subcutaneously for 20 days. From day 11 to day 20, different groups received 100, 250 or 500 mg/kg/day of powdered leaves of Costus igeus in distilled water orally or Glibenclamide 500 microg/kg orally. On the 20th day, after overnight fasting, a retro-orbital puncture was performed for obtaining blood samples to estimate the fasting blood glucose level, and the same procedure was followed on the other eye 1 hour after a glucose load of 2.5 g/kg orally for estimation of post-glucose load blood glucose levels. Fasting blood sugar and postglucose load blood sugar levels were raised in the group that received dexamethasone when compared to normal controls (P < 0.001), whereas 250 and 500 mg/kg powdered leaf of Costus igeus and Glibenclamide 500 microg/kg decreased the dexamethasone-induced hyperglycemia (P < 0.01). The leaves of Costus igeus reduced the fasting and postprandial blood sugar levels, bringing them towards normal, in dexamethasone-induced hyperglycemia in rats.
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