ArticleChemical physics letters2010
Improved Resolution in Dipolar NMR Spectra Using Constant Time Evolution PISEMA Experiment.
Article in Chemical physics letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- NMR Spectroscopy Approach to Study the Structure, Orientation, and Mechanism of the Multidrug Exporter EmrE.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Sensitivity and resolution enhancement of oriented solid-state NMR: application to membrane proteins.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- Determination of structural topology of a membrane protein in lipid bilayers using polarization optimized experiments (POE) for static and MAS solid state NMR spectroscopy.Journal of biomolecular NMR · 2013Article
- Orphan spin operators enable the acquisition of multiple 2D and 3D magic angle spinning solid-state NMR spectra.The Journal of chemical physics · 2013Article
- Very large residual dipolar couplings from deuterated ubiquitin.Journal of biomolecular NMR · 2012Article
- Multidimensional oriented solid-state NMR experiments enable the sequential assignment of uniformly 15N labeled integral membrane proteins in magnetically aligned lipid bilayers.Journal of biomolecular NMR · 2011Article
- Proton evolved local field solid-state nuclear magnetic resonance using Hadamard encoding: theory and application to membrane proteins.The Journal of chemical physics · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
The atomic structure of small molecules and polypeptides can be attained from anisotropic NMR parameters such as dipolar couplings (DC) and chemical shifts (CS). Separated local field experiments resolve DC and CS correlations into two dimensions. However, crowded NMR spectra represent a significant obstacle for the complete resolution of these anisotropic parameters. Using the PISEMA (Polarization Inversion Spin Exchange at the Magic Angle) experiment as a foundation, we designed new pulse schemes that use a constant time evolution in the dipolar (indirect) dimension to measure DC and CS correlations at high resolution. We demonstrated this approach on a 4-pentyl-4'-cyanobiphenyl (5CB) liquid crystal sample, achieving a resolution enhancement ranging from 30 to 60 % for the resonances in the dipolar dimension. These new experiments open the possibility of obtaining significant resolution enhancement for multidimensional NMR experiments carried out on oriented liquid crystalline samples as well as oriented membrane proteins.
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Registered trials
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