Evidence map›Paper›PMID 20814447›Full record

ArticleFuture virology2010

How HIV treatment could result in effective prevention.

Kartik K Venkatesh, Mark N Lurie, Kenneth H Mayer

Abstract read
In one paragraph

Article in Future virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kartik K VenkateshDepartment of Community Health, Division of Infectious Diseases, Department of Medicine, Alpert Medical School, Brown University/Miriam Hospital, RI, USA.
Mark N Lurie
Kenneth H Mayer

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Miriam/Brown/Tufts Fogarty AIDS International Training and Research ProgramD43TW000237 · FIC · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 1993 to 2014
$10.6M
Clinical Trial Unit for HIV Prevention and Microbicide ResearchU01AI069480 · NIAID · FENWAY COMMUNITY HEALTH CENTER · PI MAYER, KENNETH H · 2008 to 2011
$7.3M
Clinical Trial Unit for HIV Prevention and Microbicide ResearchUM1AI069480 · NIAID · FENWAY COMMUNITY HEALTH CENTER · PI MAYER, KENNETH H · 2012 to 2014
$2.3M
Enhancing HIV Secondary Prevention in a clinical care setting in southern IndiaF30MH079738 · NIMH · BROWN UNIVERSITY · PI VENKATESH, KARTIK KAILAS · 2006 to 2011
$270k
FIC NIH HHS D43 TW000237NIAID NIH HHS P30 AI042853NIAID NIH HHS U01 AI069480NIMH NIH HHS F30 MH079738
6 · The paper itself

Abstract

As the number of HIV infections continues to surpass treatment capacity, new HIV prevention strategies are imperative. Beyond individual clinical benefits, by rendering an individual less infectious, expanding access to highly active antiretroviral therapy (HAART) could also have a larger public health impact of curbing new HIV infections. Recent guidelines have moved towards initiating HAART at higher CD4 cell counts, thus increasing the number of individuals in need of treatment. A new treatment strategy is wanting that can simultaneously curb the epidemic and provide necessary treatment to those most in need. A recent debate has centered on whether an expansion of free and universal treatment, regardless of CD4 cell count, could be a means of HIV prevention. In light of the growing access to HAART in resource-limited settings and increasing evidence suggesting the clinical and prevention benefits of initiating treatment at higher CD4 cell counts, it is conceivable that, in the future, HAART will be an integral part of both individual-level clinical treatment programs as well as public health-based HIV prevention interventions.

Identifiers

PMID20814447
PMCPMC2929800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.