ReviewJournal of developmental and behavioral pediatrics : JDBP2010
Understanding the complex etiologies of developmental disorders: behavioral and molecular genetic approaches.
Review in Journal of developmental and behavioral pediatrics : JDBP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early childhood exposure to general anesthesia and subsequent risk of learning disabilities: a systematic review and meta-analysis of cohort studies.BMC anesthesiology · 2026Pooled it
- Using ADHD Medications to Treat Coexisting ADHD and Reading Disorders: A Systematic Review.Clinical pharmacology and therapeutics · 2018Pooled it
- The Impact of Intensive Reading Intervention on Level of Attention in Middle School Students.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2015Trial
- Associations between READ1 deletion, reading proficiency, and white matter network organisation in children with and without developmental dyslexia.Brain structure & function · 2026Article
- Translating the Power of Precision Medicine Into the World of Communication Disorders.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Computerised Attention Functions Training Versus Computerised Executive Functions Training for Children with Attention Deficit/Hyperactivity Disorder: A Randomised Controlled Trial.Journal of clinical medicine · 2024Article
- Is There an Association Between Cesarean Section Delivery with Specific Learning Disabilities (SLD) or/and Attention-Deficit/Hyperactivity Disorder (ADHD)? A Cross-Sectional Study in Greek Population.Children (Basel, Switzerland) · 2024Article
- Neurodevelopmental Impairments in Adult Psychosomatic Patients.Journal of clinical medicine · 2024Article
- Vitamin D levels of pregnant immigrant women and developmental disorders of language, learning and coordination in offspring.PloS one · 2024Article
- Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity.BMC medical genomics · 2023Article
- Attention-Deficit/Hyperactivity Disorder and Academic Functioning: Reading, Writing, and Math Abilities in a Community Sample of Youth with and without ADHD.Research on child and adolescent psychopathology · 2023Article
- Rapid auditory processing and medial geniculate nucleus anomalies in Kiaa0319 knockout mice.Genes, brain, and behavior · 2022Article
- Is executive dysfunction a potential contributor to the comorbidity between basic reading disability and attention-deficit/hyperactivity disorder?Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
- The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia.Brain sciences · 2020Article
- Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk.Development and psychopathology · 2020Article
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Understanding, educating, and supporting children with specific learning disabilities: 50 years of science and practice.The American psychologist · 2020Review
- Functional connectivity of the reading network is associated with prenatal polybrominated diphenyl ether concentrations in a community sample of 5 year-old children: A preliminary study.Environment international · 2020Article
- Behavior and Molecular Genetic Approaches to Comorbidity.Current developmental disorders reports · 2019Article
- Understanding Comorbidity Between Specific Learning Disabilities.New directions for child and adolescent development · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis article has 2 primary goals. First, a brief tutorial on behavioral and molecular genetic methods is provided for readers without extensive training in these areas. To illustrate the application of these approaches to developmental disorders, etiologically informative studies of reading disability (RD), math disability (MD), and attention-deficit hyperactivity disorder (ADHD) are then reviewed. Implications of the results for these specific disorders and for developmental disabilities as a whole are discussed, and novel directions for future research are highlighted.
methodPrevious family and twin studies of RD, MD, and ADHD are reviewed systematically, and the extensive molecular genetic literatures on each disorder are summarized. To illustrate 4 novel extensions of these etiologically informative approaches, new data are presented from the Colorado Learning Disabilities Research Center, an ongoing twin study of the etiology of RD, ADHD, MD, and related disorders.
conclusionsRD, MD, and ADHD are familial and heritable, and co-occur more frequently than expected by chance. Molecular genetic studies suggest that all 3 disorders have complex etiologies, with multiple genetic and environmental risk factors each contributing to overall risk for each disorder. Neuropsychological analyses indicate that the 3 disorders are each associated with multiple neuropsychological weaknesses, and initial evidence suggests that comorbidity between the 3 disorders is due to common genetic risk factors that lead to slow processing speed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.