ArticleAJNR. American journal of neuroradiology2010
Magnetization transfer MR imaging demonstrates degeneration of the subcortical and cortical gray matter in Huntington disease.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Magnetization transfer imaging in premanifest and manifest huntington disease: a 2-year follow-up.AJNR. American journal of neuroradiology · 2013Trial
- Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders.Brain sciences · 2025Review
- The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease.Frontiers in aging neuroscience · 2024Review
- Linking white matter and deep gray matter alterations in premanifest Huntington disease.NeuroImage. Clinical · 2016Article
- Magnetic resonance imaging striatal volumes: a biomarker for clinical trials in Huntington's disease.Movement disorders : official journal of the Movement Disorder Society · 2014Review
- Huntington disease: natural history, biomarkers and prospects for therapeutics.Nature reviews. Neurology · 2014Review
- Examination of Huntington's disease in a Chinese family.Neural regeneration research · 2014Article
- Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.Neurobiology of disease · 2013Article
- Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.PloS one · 2013Article
- Magnetization transfer imaging in premanifest and manifest Huntington disease.AJNR. American journal of neuroradiology · 2012Article
- Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis.PloS one · 2011Article
- Magnetization transfer imaging demonstrates a distributed pattern of microstructural changes of the cerebral cortex in amyotrophic lateral sclerosis.AJNR. American journal of neuroradiology · 2011Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeGM is typically affected in HD since the presymptomatic stage. Our aim was to investigate with MT MR imaging the microstructural changes of the residual brain subcortical and cortical GM in carriers of the HD gene and to preliminarily assess their correlation with the clinical features. MATERIALS AND
methodsFifteen HD gene carriers with a range of clinical severity and 15 age- and sex-matched healthy controls underwent MT MR imaging on a 1.5T scanner. The MT ratio was measured automatically in several subcortical and cortical GM regions (striatal nuclei; thalami; and the neocortex of the frontal, temporal, parietal, and occipital lobes) by using FLS tools.
resultsThe MT ratio was significantly (P < .05 with Bonferroni correction for multiple comparison) decreased in all subcortical structures except the putamen and decreased diffusely in the cerebral cortex of HD carriers compared with controls. Close correlation was observed between the subcortical and cortical regional MT ratios and several clinical variables, including disease duration, motor disability, and scores in timed neuropsychological tests.
conclusionsMT imaging demonstrates degeneration of the subcortical and cortical GM in HD carriers and might serve, along with volumetric assessment, as a surrogate marker in future clinical trials of HD.
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