ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Pooled it
- Vitamin BEuropean journal of nutrition · 2019Pooled it
- Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Pooled it
- Article
- Vitamin BNutrients · 2024Article
- A Case-Control Study of Dietary Choline Intake and Risk of Colorectal Cancer Modified by Dietary B-Vitamin Intake.Nutrients · 2024Article
- Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study.Nutrients · 2024Article
- Interactions between vitamin B2, the MTRR rs1801394 and MTR rs1805087 genetic polymorphisms, and colorectal cancer risk in a Korean population.Epidemiology and health · 2024Article
- Vitamin BScience advances · 2023Article
- Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.The American journal of clinical nutrition · 2022Article
- Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study.Nutrients · 2022Article
- Association between Serum Vitamin B12 and Global DNA Methylation in Colorectal Cancer Patients.Nutrients · 2020Article
- One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk.International journal of cancer · 2019Article
- Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.British journal of cancer · 2016Article
- Vitamin B2 intake and colorectal cancer risk; results from the Nurses' Health Study and the Health Professionals Follow-Up Study cohort.International journal of cancer · 2016Article
- Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma.International journal of molecular sciences · 2016Article
- Dietary Reference Values for vitamin B6.EFSA journal. European Food Safety Authority · 2016Article
- Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.Immunity & ageing : I & A · 2016Article
- Role of vitamins in gastrointestinal diseases.World journal of gastroenterology · 2015Review
- Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.The Journal of nutrition · 2015Article
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Authors and funding
47 authors at 8 institutions in 8 countries.
Funding
Abstract
backgroundB-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive.
methodsWe carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat.
resultsThe relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; P(trend) = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; P(trend) <0.001) for vitamin B6, and 1.02 (95% CI, 0.80-1.29; P(trend) = 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed ≥30 g alcohol/day. The polymorphisms were not associated with colorectal cancer.
conclusionsHigher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. IMPACT: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer.
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