ReviewInternational review of neurobiology2010
The genetics of behavioral alcohol responses in Drosophila.
Review in International review of neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Alternative 3' Polyadenylation Responses to Acute Ethanol Exposure Differ Between Drosophila Populations.Research square · 2026Article
- Evolution of Plasticity in Response to Ethanol Between Recently Separated Populations ofEcology and evolution · 2026Article
- Neuroecology of alcohol risk and reward: Methanol boosts pheromones and courtship success inScience advances · 2025Article
- Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons.Current biology : CB · 2025Article
- Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes.Genes, brain, and behavior · 2024Article
- Large genetic analysis of alcohol resistance and tolerance reveals an inverse correlation and suggests 'true' tolerance mutants.bioRxiv : the preprint server for biology · 2023Article
- Caffeine Delays Ethanol-Induced Sedation inBiology · 2022Article
- An Ant-Mimicking Jumping Spider Achieves Higher Predation Probability with Lower Success Rate When Exposed to Ethanol.Insects · 2022Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.Neuroscience and biobehavioral reviews · 2022Review
- TheJournal of neurogenetics · 2021Article
- Receptors and Channels Associated with Alcohol Use: Contributions fromNeuroscience insights · 2021Review
- Flying Together:International journal of molecular sciences · 2020Review
- Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.Alcoholism, clinical and experimental research · 2020Article
- Altered Actin Filament Dynamics in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Insights from intoxicated Drosophila.Alcohol (Fayetteville, N.Y.) · 2019Review
- Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.Heredity · 2018Article
- Cue-Induced Ethanol Seeking inFrontiers in physiology · 2018Article
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila melanogaster is commonly found near rotting or fermenting fruit, reflected in its name pomace, or vinegar fly. In such environments, flies often encounter significant levels of ethanol. Three observations have made Drosophila a very promising model organism to understand the genetic contributions to the behavioral responses to alcohol. First, similar to higher vertebrates, flies show hyperactivation upon exposure to a low to medium dose of alcohol, while high doses can lead to sedation. In addition, when given a choice, flies will actually prefer alcohol-containing food over regular food. Second, the genes and biochemical pathways implicated in controlling these behavioral responses in flies are also participating in determining alcohol responses, and drinking behavior in mammals. Third, the fact that flies have been studied genetically for over one hundred years means that an exceptional repertoire of genetic tools are at our disposal. Here, we will review some of these tools and experimental approaches, survey the methods for, and measures after Drosophila ethanol exposure, and discuss the different molecular components and functional pathways involved in these behavioral responses to alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.