Trial reportCardiovascular ultrasound2010
Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients.
Trial report in Cardiovascular ultrasound, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Is It Wise to Forget Exercise Stress Echocardiography in the Study of Chest Pain in Children? Comment on Huang, S.-W.; Liu, Y.-K. Pediatric Chest Pain: A Review of Diagnostic Tools in the Pediatric Emergency Department.Diagnostics (Basel, Switzerland) · 2025Article
- Comment on Fogliazza et al. Approaches to Pediatric Chest Pain: A Narrative Review.Journal of clinical medicine · 2025Article
- Clinical Application of Exercise Stress Echocardiography in an Outpatient Pediatric Population.Journal of clinical medicine · 2024Article
- Exercise-Induced Intraventricular Gradients As a Potential Cause of Sudden Cardiac Death.Cureus · 2023Article
- Intraventricular gradients-When we have to "exercise" our minds: A case report.Clinical case reports · 2023Article
- Exercise stress echocardiography: Where are we now?World journal of cardiology · 2022Review
- Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker.Ultrasound (Leeds, England) · 2021Article
- Symptomatic Exercise-induced Intraventricular Gradient in Competitive Athlete.Arquivos brasileiros de cardiologia · 2017Article
- Need for a standardized protocol for stress echocardiography in provoking subaortic and valvular gradient in various cardiac conditions.Cardiovascular ultrasound · 2014Review
- Clinical applications of exercise stress echocardiography in the treadmill with upright evaluation during and after exercise.Cardiovascular ultrasound · 2013Article
- Orthostatic stress echocardiography as a useful test to measure variability of transvalvular pressure gradients in aortic stenosis.Cardiovascular ultrasound · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUpright exercise stress echocardiography (SE) induces significant intraventricular gradient (IVG) and systolic anterior motion (SAM) in a large proportion of symptomatic athletes, who may therefore benefit from a negative inotropic therapy.The purpose of the present study was to assess the effect of chronic oral β blocker therapy on the occurrence of exercise-induced IVG and mitral valve SAM, in symptomatic athletes.
methodsWe enrolled 35 symptomatic athletes (age = 23 ± 11 years) with IVG (>30 mmHg) during SE off therapy. All repeated SE on chronic oral beta-blocker therapy (atenolol up to 50 mg, bisoprolol up to 10 mg, or metoprolol up to 100 mg daily according to physician-driven choice).
resultsOn therapy, there was during SE a reduction in IVG (35 off vs 17 on beta blocker, p < 0.01), decrease of IVG (102 ± 34 mmHg off vs 69 ± 24 mmHg on beta blocker, p < 0.01), peak heart rate (178 ± 15 bpm off vs 157 ± 9 bpm on beta blocker), SAM (24 off vs 9 on beta blocker, p < 0.001), symptoms during SE (17 off vs 2 on beta blocker p < 0.001), ST segment depression (13 off vs 2 on beta blocker, p < 0.001).
conclusionsIn athletes with positive screening on medical evaluation for sports practice and IVG on exertion, treatment with oral beta blockers improved symptoms in the large majority of patients. Symptomatic benefit was mirrored by objective evidence of improvement of echocardiographic signs of obstruction (IVG and SAM) and reduction of ischemia-like electrocardiographic changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.