ReviewAntioxidants & redox signaling2011
Redox biology: computational approaches to the investigation of functional cysteine residues.
Review in Antioxidants & redox signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Improved detection of lipidated Atg8a by immunoblotting inAutophagy · 2025Article
- Modeling predicts facile release of nitrite but not nitric oxide from the thionitrate CHScientific reports · 2024Article
- Molecular determinants of acrylamide neurotoxicity through covalent docking.Frontiers in pharmacology · 2023Article
- Homocysteinylation and Sulfhydration in Diseases.Current neuropharmacology · 2022Review
- Targeting of the intracellular redox balance by metal complexes towards anticancer therapy.Frontiers in chemistry · 2022Review
- Tris-(2-pyridyl)-pyrazolyl Borate Zinc(II) Complexes: Synthesis, DNA/Protein Binding and In Vitro Cytotoxicity Studies.Molecules (Basel, Switzerland) · 2021Article
- pCysMod: Prediction of Multiple Cysteine Modifications Based on Deep Learning Framework.Frontiers in cell and developmental biology · 2021Article
- 3D interaction homology: Hydropathic interaction environments of serine and cysteine are strikingly different and their roles adapt in membrane proteins.Current research in structural biology · 2021Article
- Non-redox cycling mechanisms of oxidative stress induced by PM metals.Free radical biology & medicine · 2020Review
- Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.Antioxidants & redox signaling · 2018Review
- Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle.Redox biology · 2018Article
- Quantitative proteomic characterization of redox-dependent post-translational modifications on protein cysteines.Molecular bioSystems · 2017Review
- Thiol-Based Redox Modulation of Soluble Guanylyl Cyclase, the Nitric Oxide Receptor.Antioxidants & redox signaling · 2017Review
- Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features.BMC bioinformatics · 2016Article
- Theoretical studies of the role of C-terminal cysteines in the process of S-nitrosylation of human Src kinases.Journal of molecular modeling · 2016Article
- Article
- H2S: A Novel Gasotransmitter that Signals by Sulfhydration.Trends in biochemical sciences · 2015Review
- Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase.Extremophiles : life under extreme conditions · 2014Article
- Thiol redox biochemistry: insights from computer simulations.Biophysical reviews · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cysteine (Cys) residues serve many functions, such as catalysis, stabilization of protein structure through disulfides, metal binding, and regulation of protein function. Cys residues are also subject to numerous post-translational modifications. In recent years, various computational tools aiming at classifying and predicting different functional categories of Cys have been developed, particularly for structural and catalytic Cys. On the other hand, given complexity of the subject, bioinformatics approaches have been less successful for the investigation of regulatory Cys sites. In this review, we introduce different functional categories of Cys residues. For each category, an overview of state-of-the-art bioinformatics methods and tools is provided, along with examples of successful applications and potential limitations associated with each approach. Finally, we discuss Cys-based redox switches, which modify the view of distinct functional categories of Cys in proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.