ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Influence of acute and chronic myocardial loading conditions, function, structural changes and extracardiac factors on NT-proBNP in asymptomatic patients with preserved ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Prognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction.Scientific reports · 2024Article
- Postoperative myocardial fibrosis assessment in aortic valvular heart diseases-a cardiovascular magnetic resonance study.European heart journal. Cardiovascular Imaging · 2023Article
- Safety and efficacy of the subclavian access route for TAVI in cases of missing transfemoral access.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Exercise tolerance in asymptomatic patients with moderate-severe valvular heart disease and preserved ejection fraction.Archives of medical science : AMS · 2012Article
- N-terminal pro-B-type natriuretic peptide in the circulation of fetuses with cardiac malformations.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
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Authors and funding
9 authors.
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Abstract
backgroundWe compared the effect of different loading conditions, parameters of structural heart disease and extracardiac confounders on NT-proBNP to validate the application of NT-proBNP for a characterisation of loading conditions and clinical course of patients with chronic heart diseases.
methodsNT-proBNP was measured in 15 controls and 34 patients with preserved ejection fraction and chronic pressure (by aortic stenosis) or volume overload (by aortic or mitral regurgitation) before and after physical as well as dobutamine stress. Myocardial fibrosis was evaluated by contrast-enhanced cardiovascular magnetic resonance.
resultsIn patients with elevated NT-proBNP due to chronic pressure or volume overloaded ventricles, physical and dobutamine stress were associated with only marginal nonsignificant additional NT-proBNP responses. Univariate analyses showed that myocardial fibrosis has the greatest effect on NT-proBNP (P < 0.01). Forward regression analyses revealed left ventricular filling, systolic function, the presence of valvular heart disease, serum creatinine and responses to dobutamine stress as independent determinants of NT-proBNP (P < 0.05 each).
conclusionNT-proBNP cannot be used simply to characterise intensity of ventricular load. Character and duration of loading conditions, cardiac structure and function, as well as confounders should be considered when NT-proBNP is used for clinical follow-up assessment.
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