ArticleAnnals of surgical oncology2011
Standardization of surgical and pathologic variables is needed in multicenter trials of adjuvant therapy for pancreatic cancer: results from the ACOSOG Z5031 trial.
Article in Annals of surgical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.Cell death & disease · 2018Pooled it
- Trial
- Teaching to the Standard: The Cancer Surgery Standards Program as a Framework for Surgical Oncology Training.Annals of surgical oncology · 2026Article
- Technical Aspects of Pancreatectomy in the Alliance A021501 Multicenter Clinical Trial of Neoadjuvant Therapy for Pancreatic Cancer: Surgical and Pathologic Documentation.JCO oncology practice · 2026Article
- Robotic Approach to Oncologic Pancreatoduodenectomy in a Case with an Aberrant Hepatic Artery Originating from the Superior Mesenteric Artery.Annals of surgical oncology · 2025Article
- Operative Standards for Cancer Care: One Step at a Time.Annals of surgical oncology · 2024Article
- ASO Practice Guidelines Series: Management of Resectable, Borderline Resectable, and Locally Advanced Pancreas Cancer.Annals of surgical oncology · 2024Review
- Neoadjuvant therapy for pancreatic cancer.Nature reviews. Clinical oncology · 2023Review
- Current status and perspectives of the future of pancreatic surgery: Establishment of evidence by integration of "art" and "science".Annals of gastroenterological surgery · 2021Review
- [Standardized diagnosis of pancreatic head carcinoma].Der Pathologe · 2021Review
- Risk-Stratified Pancreatectomy Clinical Pathway Implementation and Delayed Gastric Emptying.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- External Retraction Technique for Robotic Pancreatoduodenectomy.Journal of the American College of Surgeons · 2020Article
- Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.CA: a cancer journal for clinicians · 2020Review
- Significance of Cancer Cells at the Vein Edge in Patients with Pancreatic Adenocarcinoma Following Pancreatectomy with Vein Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Tumour origin and R1 rates in pancreatic resections: towards consilience in pathology reporting.Virchows Archiv : an international journal of pathology · 2018Article
- Neoadjuvant therapy for resectable pancreatic cancer.World journal of gastrointestinal oncology · 2017Review
- Intraoperative Frozen Section Analysis of the Pancreas: A Case Report and Review of the Literature.Case reports in pancreatic cancer · 2016Article
- Pathology of pancreatic ductal adenocarcinoma: facts, challenges and future developments.World journal of gastroenterology · 2014Review
- Preparing for prospective clinical trials: a national initiative of an excellence registry for consecutive pancreatic cancer resections.World journal of surgery · 2014Article
- Pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a French multicentre prospective evaluation of resection margins in 150 evaluable specimens.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2014Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundStandardization of surgical and pathologic techniques is crucial to the interpretation of studies evaluating adjuvant therapies for pancreatic cancer (PC).
methodsTo assess the degree to which treatment administered prior to enrollment of patients in trials of adjuvant therapy is quality controlled, the operative and pathology reports of patients in American College of Surgeons Oncology Group (ACOSOG) Z5031-a national trial of chemoradiation following pancreaticoduodenectomy (PD)-were rigorously evaluated. We analyzed variables with the potential to influence staging or outcome.
results80 patients reported to have undergone R0 (75%) or R1 (25%) pylorus-preserving (38%) or standard (62%) PD were evaluated. A search for metastases was documented in 96% of cases. The proximity of the tumor to the superior mesenteric vein was reported in 69%; vein resection was required in 9% and lateral venorrhaphy in 14%. The method of dissection along the superior mesenteric artery (SMA) was described in 68%, being ultrasonic dissection (17%), stapler (24%), and clamp and cut (59%). SMA skeletonization was described in 25%, and absence of disease following resection was documented in 24%. The surgeon reported marking the critical SMA margin in 25%; inking was documented in 65% of cases and evaluation of the SMA margin was reported in 47%. A range of 1-49 lymph nodes was evaluated. Only 34% of pathology reports met College of American Pathologists criteria.
conclusionsTrials of adjuvant therapy following PD suffer from a lack of standardization and quality control prior to patient enrollment. These data suggest areas for improvement in the design of multidisciplinary treatment protocols.
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Registered trials
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