ArticlePloS one2010
Identification of novel inhibitors of dietary lipid absorption using zebrafish.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 91 citations in OpenAlex.
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- Automated In Vivo Phenotypic Screening Platform for Identifying Factors that Affect Cell Regeneration Kinetics.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Optimized methods to image hepatic lipid droplets in zebrafish larvae.Disease models & mechanisms · 2024Article
- A novel multitask learning algorithm for tasks with distinct chemical space: zebrafish toxicity prediction as an example.Journal of cheminformatics · 2024Article
- The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity inAnimals : an open access journal from MDPI · 2024Article
- Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model.Frontiers in nutrition · 2023Article
- Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain.International journal of molecular sciences · 2022Review
- Inhibition of Intestinal Lipid Absorption by Cyanobacterial Strains in Zebrafish Larvae.Marine drugs · 2021Article
- Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases.Journal of lipid and atherosclerosis · 2021Review
- Wild-Type Zebrafish (Animals : an open access journal from MDPI · 2020Review
- Early cell-autonomous accumulation of neutral lipids during infection promotes mycobacterial growth.PloS one · 2020Article
- Application of the Transcriptional Disease Signature (TDSs) to Screen Melanoma-Effective Compounds in a Small Fish Model.Scientific reports · 2019Article
- Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae.Frontiers in pharmacology · 2019Review
- Isobavachalcone fromInternational journal of molecular sciences · 2018Article
- Lipid-Lowering Effect of thePolymers · 2018Article
- How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.Genetics · 2018Review
- Human genetic variation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Physiological reviews · 2017Review
- An HPLC-CAD/fluorescence lipidomics platform using fluorescent fatty acids as metabolic tracers.Journal of lipid research · 2017Article
- Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish.Frontiers in endocrinology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Pharmacological inhibition of dietary lipid absorption induces favorable changes in serum lipoprotein levels in patients that are at risk for cardiovascular disease and is considered an adjuvant or alternative treatment with HMG-CoA reductase inhibitors (statins). Here we demonstrate the feasibility of identifying novel inhibitors of intestinal lipid absorption using the zebrafish system. A pilot screen of an unbiased chemical library identified novel compounds that inhibited processing of fluorescent lipid analogues in live zebrafish larvae. Secondary assays identified those compounds suitable for testing in mammals and provided insight into mechanism of action, which for several compounds could be distinguished from ezetimibe, a drug used to inhibit cholesterol absorption in humans that broadly inhibited lipid absorption in zebrafish larvae. These findings support the utility of zebrafish screening assays to identify novel compounds that target complex physiological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.