Trial reportPloS one2010
The effect of opioid receptor blockade on the neural processing of thermal stimuli.
Trial report in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419858 (The Role of Endogenous Opioidergic Systems in Breathing Based Analgesia), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Endogenous Opioidergic Systems in Breathing Based Analgesia
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Endogenous opioid antagonism in physiological experimental pain models: a systematic review.PloS one · 2015Pooled it
- Neuroimaging of the periaqueductal gray: state of the field.NeuroImage · 2012Pooled it
- Shared effects of the opioid antagonist naltrexone on first-hand and empathic pain.Social cognitive and affective neuroscience · 2026Trial
- Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
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- Comparing neural responses to cutaneous heat and pressure pain in healthy participants.Scientific reports · 2025Article
- Supraspinal Mechanisms Underlying Ocular Pain.Frontiers in medicine · 2021Review
- The role of the opioid system in decision making and cognitive control: A review.Cognitive, affective & behavioral neuroscience · 2019Review
- Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system.eLife · 2018Article
- Opioid-Independent and Opioid-Mediated Modes of Pain Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Resolving the Brainstem Contributions to Attentional Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neurobiological Aspects of Mindfulness in Pain Autoregulation: Unexpected Results from a Randomized-Controlled Trial and Possible Implications for Meditation Research.Frontiers in human neuroscience · 2016Article
- The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.Pain and therapy · 2015Article
- Spinal cord-midbrain functional connectivity is related to perceived pain intensity: a combined spino-cortical FMRI study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Common representation of pain and negative emotion in the midbrain periaqueductal gray.Social cognitive and affective neuroscience · 2013Article
- The endogenous opioids related with antinociceptive effects induced by electrical stimulation into the amygdala.The open dentistry journal · 2013Article
- Endogenous analgesia, dependence, and latent pain sensitization.Current topics in behavioral neurosciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endogenous opioid system represents one of the principal systems in the modulation of pain. This has been demonstrated in studies of placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or by cognitive states is blocked by opioid antagonists. The aim of this study was to characterize the effect of opioid receptor blockade on the physiological processing of painful thermal stimulation in the absence of cognitive manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses and intensity ratings to non-painful and painful thermal stimuli in a double-blind, cross-over design using the opioid receptor antagonist naloxone. On the behavioral level, we observed an increase in intensity ratings under naloxone due mainly to a difference in the non-painful stimuli. On the neural level, painful thermal stimulation was associated with a negative BOLD signal within the pregenual anterior cingulate cortex, and this deactivation was abolished by naloxone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.