ArticleHFSP journal2010
Mechanisms of short-term plasticity at neuromuscular active zones of Drosophila.
Article in HFSP journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Presynaptic quantal size enhancement counteracts post-tetanic release depression.The Journal of physiology · 2025Article
- Versatile Endogenous Editing of GluRIIA inCells · 2024Article
- Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling inFrontiers in synaptic neuroscience · 2023Article
- Short-Term Synaptic Plasticity: Microscopic Modelling and (Some) Computational Implications.Advances in experimental medicine and biology · 2022Article
- Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:CaeLife · 2020Article
- Article
- Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.The Journal of cell biology · 2019Article
- The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.EMBO reports · 2019Article
- Estimation of the Readily Releasable Synaptic Vesicle Pool at theBio-protocol · 2019Article
- Article
- ELKS active zone proteins as multitasking scaffolds for secretion.Open biology · 2018Review
- Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.The Journal of cell biology · 2017Article
- Determining synaptic parameters using high-frequency activation.Journal of neuroscience methods · 2016Article
- Synaptic Vesicle Proteins and Active Zone Plasticity.Frontiers in synaptic neuroscience · 2016Article
- Synapsin is required to "boost" memory strength for highly salient events.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DURING SHORT BURSTS OF NEURONAL ACTIVITY, CHANGES IN THE EFFICACY OF NEUROTRANSMITTER RELEASE ARE GOVERNED PRIMARILY BY TWO COUNTERACTING PROCESSES: (1) Ca(2+)-dependent elevations of vesicle release probability and (2) depletion of synaptic vesicles. The dynamic interplay of both processes contributes to the expression of activity-dependent synaptic plasticity. Here, we exploited various facets of short-term plasticity at the Drosophila neuromuscular junction to dissect these two processes. This enabled us to rigorously analyze different models of synaptic vesicle pools in terms of their size and mobilization properties. Independent of the specific model, we estimate approximately 300 readily releasable vesicles with an average release probability of approximately 50% in 1 mM extracellular calcium ( approximately 5% in 0.4 mM extracellular calcium) under resting conditions. The models also helped interpreting the altered short-term plasticity of the previously reported mutant of the active zone component Bruchpilot (BRP). Finally, our results were independently confirmed through fluctuation analysis. Our data reveal that the altered short-term plasticity observed in BRP mutants cannot be accounted for by delocalized Ca(2+) channels alone and thus suggest an additional role of BRP in short-term plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.