ArticleNeurology2010
Albuminuria and the risk of incident stroke and stroke types in older adults.
Article in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Trial
- Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes.BMC medicine · 2022Trial
- Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.Neurology · 2016Trial
- Kidney function and risk of cardiovascular disease and mortality in kidney transplant recipients: the FAVORIT trial.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Trial
- Association of Serum Cystatin C with Stroke Morbidity and All-Cause and Cardio-Cerebrovascular Mortality: Evidence from the NHANES.Healthcare (Basel, Switzerland) · 2025Article
- An elevated urinary albumin-to-creatinine ratio increases the risk of incident cardia-cerebrovascular disease in individuals with type 2 diabetes.Diabetology & metabolic syndrome · 2024Article
- Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Effects of estimated glomerular filtration rate on clinical outcomes in patients with intracerebral hemorrhage.BMC neurology · 2022Article
- Urinary albumin-to-creatinine ratio and the risk of first stroke in Chinese hypertensive patients treated with angiotensin-converting enzyme inhibitors.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Article
- Low grade albuminuria as a risk factor for subtypes of stroke - the HUNT Study in Norway.BMC neurology · 2020Article
- Chinese ASCVD risk equations rather than pooled cohort equations are better to identify macro- and microcirculation abnormalities.BMC cardiovascular disorders · 2020Article
- The Risk of Major Hemorrhage with CKD.Journal of the American Society of Nephrology : JASN · 2016Article
- Recurrent Intracerebral Hemorrhage: Associations with Comorbidities and Medicine with Antithrombotic Effects.PloS one · 2016Article
- Association of Kidney Disease Measures with Cause-Specific Mortality: The Korean Heart Study.PloS one · 2016Article
- Proteinuria Is an Independent Risk Factor for First Incident Stroke in Adults Under Treatment for Hypertension in China.Journal of the American Heart Association · 2015Article
- Renal dysfunction is associated with deep cerebral microbleeds but not white matter hyperintensities in patients with acute intracerebral hemorrhage.Journal of neurology · 2015Observational
- Proteinuria, but Not eGFR, Predicts Stroke Risk in Chronic Kidney Disease: Chronic Renal Insufficiency Cohort Study.Stroke · 2015Observational
- Risk Factors for Lobar and Non-Lobar Intracerebral Hemorrhage in Patients with Vascular Disease.PloS one · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe kidney biomarker that best reflects risk of stroke is unknown. We sought to evaluate the association of stroke with 3 kidney biomarkers: albuminuria, cystatin C, and glomerular filtration rate.
methodsThese 3 biomarkers were determined in 3,287 participants without history of stroke from the Cardiovascular Health Study, a longitudinal cohort study of men and women age 65 years and older from 4 US communities. The biomarkers were albuminuria ascertained using urinary albumin-to-creatinine ratio (UACR) from morning spot urine, creatinine-based estimated glomerular filtration rate (eGFR), and cystatin C. Outcomes were incident stroke (any, ischemic, or hemorrhagic) during follow-up between 1996 and 2006.
resultsA total of 390 participants had an incident stroke: 81% ischemic, 12% hemorrhagic, and 7% unclassified. In adjusted Cox regression models, UACR was more strongly related to any stroke, ischemic stroke, and hemorrhagic stroke than eGFR and cystatin C. The hazard ratio (HR) of any stroke comparing the top to bottom quintile of UACR was 2.10 (95% confidence interval [CI] 1.47-3.00), while HR for eGFR was 1.29 (95% CI 0.91-1.84) and for cystatin C was 1.22 (95% CI 0.85-1.74). When considering clinically relevant categories, elevated UACR was associated with increased hazard of any stroke and ischemic stroke regardless of eGFR or cystatin C categories.
conclusionsUACR was the kidney biomarker most strongly associated with risk of incident stroke. Results in this elderly cohort may not be applicable to younger populations. These findings suggest that measures of glomerular filtration and permeability have differential effects on stroke risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.