ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Chemical coding for cardiovascular sympathetic preganglionic neurons in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat.The Journal of comparative neurology · 2026Article
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
- Article
- Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice.Nature communications · 2024Article
- Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice.Scientific reports · 2024Article
- The autonomic innervation of hairy skin in humans: an in vivo confocal study.Scientific reports · 2019Article
- TFOS DEWS II pain and sensation report.The ocular surface · 2017Review
- Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes.British journal of pharmacology · 2016Review
- Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells.Developmental neurobiology · 2016Article
- Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.The Journal of physiology · 2014Article
- Neural pathways that control the glucose counterregulatory response.Frontiers in neuroscience · 2014Review
- Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells.Neural regeneration research · 2013Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Cocaine and amphetamine-regulated transcript peptide (CART) is present in a subset of sympathetic preganglionic neurons in the rat. We examined the distribution of CART-immunoreactive terminals in rat stellate and superior cervical ganglia and adrenal gland and found that they surround neuropeptide Y-immunoreactive postganglionic neurons and noradrenergic chromaffin cells. The targets of CART-immunoreactive preganglionic neurons in the stellate and superior cervical ganglia were shown to be vasoconstrictor neurons supplying muscle and skin and cardiac-projecting postganglionic neurons: they did not target non-vasoconstrictor neurons innervating salivary glands, piloerector muscle, brown fat, or adrenergic chromaffin cells. Transneuronal tracing using pseudorabies virus demonstrated that many, but not all, preganglionic neurons in the vasoconstrictor pathway to forelimb skeletal muscle were CART immunoreactive. Similarly, analysis with the confocal microscope confirmed that 70% of boutons in contact with vasoconstrictor ganglion cells contained CART, whereas 30% did not. Finally, we show that CART-immunoreactive cells represented 69% of the preganglionic neuron population expressing c-Fos after systemic hypoxia. We conclude that CART is present in most, although not all, cardiovascular preganglionic neurons but not thoracic preganglionic neurons with non-cardiovascular targets. We suggest that CART immunoreactivity may identify the postulated "accessory" preganglionic neurons, whose actions may amplify vasomotor ganglionic transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.