Evidence map›Paper›PMID 20810877›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2010

Preservation and modulation of specific left hemisphere regions is vital for treated recovery from anomia in stroke.

Julius Fridriksson

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.

  1. Guideline
  2. Intensity of aphasia therapy: evidence and efficacy.Current neurology and neuroscience reports · 2011
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Improved naming in patients with Broca's aphasia with tDCS.Journal of neurology, neurosurgery, and psychiatry · 2024
    Trial
  7. Trial
  8. Lesion-site-dependent responses to therapy after aphasic stroke.Journal of neurology, neurosurgery, and psychiatry · 2018
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, USA. jfridrik@sc.edu
University of South Carolina · US

Funding

Neural Predictors of Anomia Recovery in AphasiaR01DC008355 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2007 to 2011
$1.7M
NIDCD NIH HHS DC008355NIDCD NIH HHS R01 DC008355
6 · The paper itself

Abstract

The location and extent of brain changes that support recovery in chronic stroke is probably related to the structural integrity of the remaining cortex. However, little is known about the specifics of this relationship and how it influences treatment outcome in chronic stroke. To examine this issue, the current study examined frank brain damage and changes in cortical activation as predictors of language-treatment outcome in patients with chronic aphasia caused by stroke. Twenty-six patients received multiple MRI sessions before and after 30 h of aphasia treatment targeting anomia, an impairment in the ability to name common objects. Improved naming was associated with increased brain activation in the anterior and posterior regions of the left hemisphere, whereas damage to the posterior portion of the left middle temporal lobe and the temporal-occipital junction had a particularly negative effect on treatment outcome. Specifically, patients whose brain damage included regions commonly associated with lexical retrieval and phonological processing (e.g., Brodmann's areas 37 and 39) were less likely to show treatment-related improvement in correct naming compared with cases where the same areas were intact. These findings suggest that brain changes associated with improved naming ability in chronic aphasia rely on preservation and recruitment of eloquent cortex in the left hemisphere. In general, it seems likely that a similar relationship between cortical preservation and recruitment may also pertain to recovery from other functional impairments in chronic stroke.

Indexed as

Recovery of FunctionAgedAnomiaAphasiaCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsRecruitment, NeurophysiologicalStroke

Identifiers

PMID20810877
PMCPMC2938788
OpenAlexW2045587988

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.