ArticleThe American journal of tropical medicine and hygiene2010
Reactions following completion of 1 and 2 year multidrug therapy (MDT).
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A systematic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction.PLoS neglected tropical diseases · 2013Pooled it
- Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients.PLoS neglected tropical diseases · 2017Trial
- International open trial of uniform multidrug therapy regimen for leprosy patients: Findings & implications for national leprosy programmes.The Indian journal of medical research · 2016Trial
- Comparison of Efficacy and Safety of Ciclosporin to Prednisolone in the Treatment of Erythema Nodosum Leprosum: Two Randomised, Double Blind, Controlled Pilot Studies in Ethiopia.PLoS neglected tropical diseases · 2016Trial
- Dovramilast for Erythema Nodosum Leprosum in Patients With Leprosy in Nepal: Protocol for a Phase 2 Open-Label Pilot Study.JMIR research protocols · 2026Article
- Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study.PLoS neglected tropical diseases · 2026Article
- Multibacillary leprosy relapse presenting as hypopigmented patches and concurrent erythema nodosum leprosum after initial multidrug therapy.Dermatology online journal · 2026Article
- Therapeutic failure of multidrug therapy for leprosy: A retrospective case series in a hyperendemic Brazilian City.PLoS neglected tropical diseases · 2025Article
- Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal.BMC health services research · 2025Article
- Exploring the experiences of leprosy stigma among patients and healthcare workers in Norte de Santander, Colombia.PLOS global public health · 2025Article
- Hypogonadism and associated factors among male Leprosy patients.PLoS neglected tropical diseases · 2024Article
- Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos.Experimental neurology · 2022Article
- Clinical, epidemiological, and laboratory prognostic factors in patients with leprosy reactions: A 10-year retrospective cohort study.Frontiers in medicine · 2022Article
- Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management.Journal of tropical medicine · 2022Review
- Article
- Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy.PLoS neglected tropical diseases · 2018Article
- In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin.PloS one · 2017Article
- Viral Co-infection and Leprosy Outcomes: A Cohort Study.PLoS neglected tropical diseases · 2015Article
- The DermLep Study I: Results of Prospective Nation-Wide Survey of the Number & Profile of Leprosy Patients seen by Dermatologists in India.Indian dermatology online journalArticle
- What is New in the Pathogenesis and Management of Erythema Nodosum Leprosum.Indian dermatology online journalReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the incidence, severity, and duration of reactional states in 139 multibacillary (MB) leprosy patients in the first 2 years after the completion of the 1 year regimen of multidrug therapy (MDT) currently recommended by the World Health Organization (WHO) and compared those findings with 295 MB leprosy patients treated with the same regimen previously recommended for 2 years. During the first year after the completion of 1 year MDT, patients experienced 1 or more reactional states 27% of the time, the vast majority being lepra type 1 reactions (reversal reactions, RR), whereas patients who received 2 year MDT experienced a reactional state during that time period only 8% of the time (P < 0.001). Furthermore, during the first year after the completion of therapy, and during the first 2 years, both the number of reactional states and reversal reactions were significantly (P < or = 0.004) more frequent, severe, of longer duration, and more commonly associated with neuritis.
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