ArticleJournal of clinical microbiology2010
Dabigatran inhibits Staphylococcus aureus coagulase activity.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06650501 (Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of theBMJ open · 2025Article
- Enhanced platelets aggregation and coagulation of methicillin-resistant Staphylococcus aureus compared to methicillin-sensitive Staphylococcus aureus.Thrombosis journal · 2025Article
- Article
- Should We Give Antithrombotic Therapy to Patients With Infective Endocarditis?: A Serious Question, But Unresolved.JACC. Advances · 2024Article
- Bilobetin attenuates Staphylococcus aureus virulence by targeting Von Willebrand factor-binding protein and staphylocoagulase.World journal of microbiology & biotechnology · 2023Article
- Phage activity against Staphylococcus aureus is impaired in plasma and synovial fluid.Scientific reports · 2023Article
- The Role of Platelets in Infective Endocarditis.International journal of molecular sciences · 2023Review
- DNA and histones impair the mechanical stability and lytic susceptibility of fibrin formed by staphylocoagulase.Frontiers in immunology · 2023Article
- The Response and Survival Mechanisms ofFoods (Basel, Switzerland) · 2022Article
- Isovitexin Is a Direct Inhibitor ofJournal of microbiology and biotechnology · 2021Article
- Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcome.Frontiers in cell and developmental biology · 2021Review
- Multimodal imaging of bacterial-host interface in mice and piglets withScience translational medicine · 2020Article
- Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity.Medical microbiology and immunology · 2019Review
- Quercetin protects rats from catheter-related Staphylococcus aureus infections by inhibiting coagulase activity.Journal of cellular and molecular medicine · 2019Article
- Review
- Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis.PloS one · 2019Article
- An Inhibitory Effect of Dryocrassin ABBA onFrontiers in microbiology · 2019Article
- Article
- Staphylococcus aureus Aggregation and Coagulation Mechanisms, and Their Function in Host-Pathogen Interactions.Advances in applied microbiology · 2016Review
- The role of hemostasis in infective endocarditis.Current infectious disease reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.