Evidence map›Paper›PMID 20810644›Full record

ArticleGenes & development2010

The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule?

Tatjana Trcek, Robert H Singer

Open access · diamondAbstract readComment
In one paragraph

Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Subcellular mRNA localisation at a glance.Journal of cell science · 2014
    Review
  7. Review
  8. Review
  9. Neuronal mRNAs travel singly into dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  10. The function of introns.Frontiers in genetics · 2012
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tatjana TrcekAlbert Einstein College of Medicine, Bronx, New York 10461, USA.
Robert H Singer
Albert Einstein College of Medicine · US

Funding

RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITUR01GM057071 · NIGMS · YESHIVA UNIVERSITY · PI SINGER, ROBERT H · 1998 to 2019
$5.7M
Mechanism of Actin mRNA LocalizationR01GM084364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2008 to 2012
$1.9M
NIGMS NIH HHS GM57071NIGMS NIH HHS R01 GM057071NIGMS NIH HHS R01 GM084364
6 · The paper itself

Abstract

She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

Indexed as

RNA TransportTranscription, GeneticAnimalsCell DifferentiationCytoplasmDrosophilaProtein BindingProtein BiosynthesisProtein TransportRibonucleoproteinsRNA Polymerase IIRNA StabilitySaccharomyces cerevisiaemessenger ribonucleoproteinRibonucleoproteinsRNA Polymerase II

Identifiers

PMID20810644
PMCPMC2932966
OpenAlexW2123878244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.