ArticleProceedings. Biological sciences2011
How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Selective Breeding for Voluntary Wheel-Running Behavior in Mice is not Associated with Reduced Lifetime Reproductive Success or Lifespan Under Long-Term Paired Breeding Conditions.Behavior genetics · 2026Article
- Early-life exercise effects on Achilles tendon in mice selectively bred for high voluntary wheel-running behavior.Physiological reports · 2025Article
- Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?Behavior genetics · 2025Article
- Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading.Calcified tissue international · 2024Article
- Effects of long-term voluntary wheel running and selective breeding for wheel running on femoral nutrient canals.Journal of anatomy · 2024Article
- Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior.PloS one · 2024Article
- Maternal upbringing and selective breeding for voluntary exercise behavior modify patterns of DNA methylation and expression of genes in the mouse brain.Genes, brain, and behavior · 2023Article
- Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does.Sports medicine and health science · 2023Article
- Multiple solutions at the genomic level in response to selective breeding for high locomotor activity.Genetics · 2023Article
- Trade-offs in muscle physiology in selectively bred high runner mice.The Journal of experimental biology · 2022Article
- Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice.Journal of anatomy · 2022Article
- Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice.Journal of anatomy · 2021Article
- Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice.Genetics · 2020Article
- Phosphorylation of CRY1 Serine 71 Alters Voluntary Activity but Not Circadian Rhythms In Vivo.Journal of biological rhythms · 2019Article
- Effects of selective breeding for high voluntary wheel-running behavior on femoral nutrient canal size and abundance in house mice.Journal of anatomy · 2018Article
- Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice.Physiology & behavior · 2017Article
- Article
- Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes.Physiology & behavior · 2017Article
- Sex-dependent differences in voluntary physical activity.Journal of neuroscience research · 2017Review
- Hormones and the Evolution of Complex Traits: Insights from Artificial Selection on Behavior.Integrative and comparative biology · 2016Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The response to uniform selection may occur in alternate ways that result in similar performance. We tested for multiple adaptive solutions during artificial selection for high voluntary wheel running in laboratory mice. At generation 43, the four replicate high runner (HR) lines averaged 2.85-fold more revolutions per day as compared with four non-selected control (C) lines, and females ran 1.11-fold more than males, with no sex-by-linetype interaction. Analysis of variance indicated significant differences among C lines but not among HR for revolutions per day. By contrast, average speed varied significantly among HR lines, but not among C, and showed a sex-by-linetype interaction, with the HR/C ratio being 2.02 for males and 2.45 for females. Time spent running varied among both HR and C lines, and showed a sex-by-linetype interaction, with the HR/C ratio being 1.52 for males but only 1.17 for females. Thus, females (speed) and males (speed, but also time) evolved differently, as did the replicate selected lines. Speed and time showed a trade-off among HR but not among C lines. These results demonstrate that uniform selection on a complex trait can cause consistent responses in the trait under direct selection while promoting divergence in the lower-level components of that trait.
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