ReviewTrends in molecular medicine2010
The emerging roles of melanopsin in behavioral adaptation to light.
Review in Trends in molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05383690 (Effects of Litebook EDGE™ Phototherapy on Academic Performance and Functional Brain Activity in Non-Depressed Adolescents), which is not on this map. Cited by 90 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Litebook EDGE™ Phototherapy on Academic Performance and Functional Brain Activity in Non-Depressed Adolescents
Who cites it
90 citing papers in PubMed, 200 citations in OpenAlex.
- Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Difference in autonomic nervous effect of blue light depending on the angle of incidence on the eye.BMC research notes · 2020Trial
- Effects of blue light and caffeine on mood.Psychopharmacology · 2014Trial
- Photic memory for executive brain responses.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Bright light for weight loss: results of a controlled crossover trial.Obesity facts · 2013Trial
- Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.Japanese journal of ophthalmology · 2026Review
- Therapeutic prospects of bright light therapy in addictive disorders: a scoping review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Chronic exposure to LED lighting impairs prefrontal cortex-dependent cognitive functions in adolescent rats.Scientific reports · 2026Article
- Circadian clock control of breast cancer hallmarks: molecular mechanisms and therapeutic implications.Cancer metastasis reviews · 2026Review
- Family History and Solar Insolation in Bipolar I Disorder.Acta psychiatrica Scandinavica · 2026Article
- Circadian rhythms in the tumor microenvironment: spatiotemporal immune regulation and chronotherapeutic opportunities.Frontiers in immunology · 2026Review
- Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review).Molecular medicine reports · 2026Review
- Targeting Cryptochromes in Chronic Diseases.Cell biology international · 2025Review
- Optimizing the Potential Utility of Blue-Blocking Glasses for Sleep and Circadian Health.Translational vision science & technology · 2025Article
- Light Influences Time-of-Day Differences in the Expression of Clock Genes and Redox Genes Involved in Glutathione Homeostasis in the Lens.Investigative ophthalmology & visual science · 2025Article
- Is there direct photoentrainment in the goldfish liver? Wavelength-dependent regulation of clock genes and investigation of the opsin 7 family.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research.Nature metabolism · 2025Review
- The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1.Journal of sleep research · 2025Article
- Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease.Nature communications · 2025Article
- Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder.International journal of bipolar disorders · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The adaptation of behavior and physiology to changes in the ambient light level is of crucial importance to life. These adaptations include the light modulation of neuroendocrine function and temporal alignment of physiology and behavior to the day:night cycle by the circadian clock. These non-image-forming (NIF) responses can function independent of rod and cone photoreceptors but depend on ocular light reception, suggesting the participation of novel photoreceptors in the eye. The discovery of melanopsin in intrinsically photosensitive retinal ganglion cells (ipRGCs) and genetic proof for its important role in major NIF responses have offered an exciting entry point to comprehend how mammals adapt to the light environment. Here, we review the recent advances in our understanding of the emerging roles of melanopsin and ipRGCs. These findings now offer new avenues to understand the role of ambient light in sleep, alertness, dependent physiologies and potential pharmacological intervention as well as lifestyle modifications to improve the quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.