ReviewCurrent opinion in structural biology2010
Unmet challenges of structural genomics.
Review in Current opinion in structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Determination of the Crystal Structure of the Cell Wall-Anchored Proteins and Pilins.Methods in molecular biology (Clifton, N.J.) · 2024Article
- CMM-An enhanced platform for interactive validation of metal binding sites.Protein science : a publication of the Protein Society · 2023Article
- Reduced B cell antigenicity of Omicron lowers host serologic response.Cell reports · 2022Article
- Reduced antigenicity of Omicron lowers host serologic response.bioRxiv : the preprint server for biology · 2022Article
- Pre- and Post-publication Verification for Reproducible Data Mining in Macromolecular Crystallography.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Article
- The CASP13-CAPRI targets as case studies to illustrate a novel scoring pipeline integrating CONSRANK with clustering and interface analyses.BMC bioinformatics · 2020Article
- High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur.Molecules (Basel, Switzerland) · 2019Review
- Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum.Acta crystallographica. Section F, Structural biology communications · 2018Article
- Molstack-Interactive visualization tool for presentation, interpretation, and validation of macromolecules and electron density maps.Protein science : a publication of the Protein Society · 2018Article
- Article
- Databases, Repositories, and Other Data Resources in Structural Biology.Methods in molecular biology (Clifton, N.J.) · 2017Review
- The impact of structural genomics: the first quindecennial.Journal of structural and functional genomics · 2016Review
- Safeguarding Structural Data Repositories against Bad Apples.Structure (London, England : 1993) · 2016Review
- Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.Acta crystallographica. Section D, Structural biology · 2016Article
- Using support vector machines to improve elemental ion identification in macromolecular crystal structures.Acta crystallographica. Section D, Biological crystallography · 2015Article
- X-ray crystallography over the past decade for novel drug discovery - where are we heading next?Expert opinion on drug discovery · 2015Review
- Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining.IUCrJ · 2014Article
- The future of crystallography in drug discovery.Expert opinion on drug discovery · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Structural genomics (SG) programs have developed during the last decade many novel methodologies for faster and more accurate structure determination. These new tools and approaches led to the determination of thousands of protein structures. The generation of enormous amounts of experimental data resulted in significant improvements in the understanding of many biological processes at molecular levels. However, the amount of data collected so far is so large that traditional analysis methods are limiting the rate of extraction of biological and biochemical information from 3D models. This situation has prompted us to review the challenges that remain unmet by SG, as well as the areas in which the potential impact of SG could exceed what has been achieved so far.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.