Evidence map›Paper›PMID 20809800›Full record

ReviewAnnual review of genetics2010

Circadian control of global gene expression patterns.

Colleen J Doherty, Steve A Kay

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Epileptiform Activity and Seizure Risk Follow Long-Term Non-Linear Attractor Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Thousands of oscillating LncRNAs in the mouse testis.Computational and structural biotechnology journal · 2024
    Article
  8. Life in the margins: the effect of immersion/emersion and tidal cycle on the North Atlantic limpet Patella vulgata protein synthesis rates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Dominant constraints on the evolution of rhythmic gene expression.Computational and structural biotechnology journal · 2023
    Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Colleen J DohertySection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA. cdoherty@ucsd.edu
Steve A Kay

Funding

GENETIC ANALYSIS OF CIRCADIAN RHYTHMS IN ARABIDOPSISR01GM056006 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A, PRUNEDA-PAZ, JOSE L · 1996 to 2016
$6.0M
Role of Ror proteins in the mammalian circadian clockR01GM074868 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A · 2006 to 2014
$3.2M
NIGMS NIH HHS R01 GM056006NIGMS NIH HHS R01 GM074868
6 · The paper itself

Abstract

An internal time-keeping mechanism has been observed in almost every organism studied from archaea to humans. This circadian clock provides a competitive advantage in fitness and survival ( 18, 30, 95, 129, 137 ). Researchers have uncovered the molecular composition of this internal clock by combining enzymology, molecular biology, genetics, and modeling approaches. However, understanding the mechanistic link between the clock and output responses has been elusive. In three model organisms, Arabidopsis thaliana, Drosophila melanogaster, and Mus musculus, whole-genome expression arrays have enabled researchers to investigate how maintaining a time-keeping mechanism connects to an adaptive advantage. Here, we review the impacts transcriptomics have had on our understanding of the clock and how this molecular clock connects with system-level circadian responses. We explore the discoveries made possible by high-throughput RNA assays, the network approaches used to investigate these large transcript datasets, and potential future directions.

Indexed as

Circadian RhythmGene Expression RegulationAnimalsArabidopsisCircadian ClocksDrosophila melanogasterHumansMice

Identifiers

PMID20809800
PMCPMC4251774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.