ArticleJournal of neurotrauma2010
Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury.
Article in Journal of neurotrauma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Multimodal cortical and subcortical exercise compared with treadmill training for spinal cord injury.PloS one · 2018Trial
- Effects of Virtual Reality Therapy Combined With Conventional Rehabilitation on Pain, Kinematic Function, and Disability in Patients With Chronic Neck Pain: Randomized Controlled Trial.JMIR serious games · 2024Article
- Review
- Effects of exercise training on neurological recovery, TGF-β1, HIF-1α, and Nogo-NgR signaling pathways after spinal cord injury in rats.Clinics (Sao Paulo, Brazil) · 2023Article
- A Novel Virtual Reality Technique (Cervigame®) Compared to Conventional Proprioceptive Training to Treat Neck Pain: A Randomized Controlled Trial.Journal of biomedical physics & engineering · 2019Article
- TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection.Experimental neurology · 2014Article
- Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion.Brain research · 2013Article
- Transplantation of Nogo-66 receptor gene-silenced cells in a poly(D,L-lactic-co-glycolic acid) scaffold for the treatment of spinal cord injury.Neural regeneration research · 2013Article
- Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice.Journal of neurotrauma · 2012Article
- Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways.Experimental neurology · 2012Article
- Technologies and combination therapies for enhancing movement training for people with a disability.Journal of neuroengineering and rehabilitation · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We tested the ability of two plasticity-promoting approaches to enhance recovery in a mouse model of incomplete spinal cord injury (SCI). Genetically, we reduced myelin-mediated inhibition of neural plasticity through Nogo66-receptor (NgR) gene deletion. Behaviorally, we utilized a novel multimodal exercise training paradigm. Adult mice of wild-type or NgR-null genotype were subjected to partial lateral hemisection (LHx) at C3-C4 with the intent of producing anatomically and functionally mild deficits. Exercise training or control treatment proceeded for 14 weeks. Behavioral outcomes were assessed prior to tract tracing and histological analysis. Genotype and training exerted differing effects on performance; training improved performance on a test related to the training regimen (task-specific benefit), whereas genotype also improved performance on more generalized behaviors (task-non-specific benefit). There were no significant histological differences across genotype or training assignment with regard to lesion size or axonal tract staining. Thus either NgR gene deletion or exercise training benefits mice with mild cervical spinal injury. In this lesion model, the effects of NgR deletion and training were not synergistic for the tasks assessed. Further work is required to optimize the interaction between pharmacological and physical interventions for SCI.
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Registered trials
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