ArticleInternational journal of colorectal disease2010
Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer.
Article in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival.Diagnostics (Basel, Switzerland) · 2021Article
- Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages.BMC cancer · 2018Article
- The combination of early treatment response and ypT stage is a novel metric to stage rectal cancer patients treated with neoadjuvant chemoradiotherapy.Oncotarget · 2017Article
- Survival implications of pretreatment pelvic CT in rectal cancer patients after neoadjuvant chemoradiotherapy and surgery.International journal of clinical and experimental medicine · 2015Article
- Distal dissection in total mesorectal excision, and preoperative chemoradiotherapy and lateral lymph node dissection for rectal cancer.Surgery today · 2014Review
- Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.Oncotarget · 2014Article
- STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.International journal of cancer · 2014Article
- Biomarkers for predicting future metastasis of human gastrointestinal tumors.Cellular and molecular life sciences : CMLS · 2013Review
- Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery.Radiation oncology (London, England) · 2013Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the prognostic significance of the response of primary rectal lesions to preoperative radiotherapy, pathological nodal status, and carcinoembryonic antigen (CEA) levels before and after radiotherapy in rectal cancer patients treated with a total mesorectal excision.
methodsWe investigated the prognostic significance of the clinical and pathological factors in 97 patients treated with preoperative radiotherapy (50-50.4 Gy over 5-6 weeks) followed by curative resections.
resultsA high CEA level (>5 ng/mL) after radiotherapy (hazard ratio, 2.849; 95% confidence interval, 1.061-7.651; p = 0.0377) and pathological lymph node metastasis (hazard ratio, 0.350; 95% confidence interval, 0.154-0.797; p = 0.0124) were independently associated with postoperative recurrence. Although the CEA level before radiotherapy was associated with disease-free survival in a univariate analysis, it lost its statistical significance in a multivariate analysis. The response of the primary rectal lesions, evaluated pathologically by T stage and the degree of regression, was not associated with disease-free survival. In patients without lymph node metastasis, the 5-year disease-free survival of those with a high CEA level after radiotherapy was significantly worse than those with low CEA after radiotherapy (61.6% vs. 89.0%, respectively, p = 0.0234).
conclusionsPathological lymph node metastasis and a high CEA level after radiotherapy were independent predictors of a poor outcome in rectal cancer patients treated with preoperative radiotherapy. The CEA level after radiotherapy was capable of discriminating patients with a high risk of recurrence among pathologically node-negative patients.
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