ArticleNaunyn-Schmiedeberg's archives of pharmacology2010
Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments.Cardiovascular toxicology · 2026Article
- A potential role for trace amines in the treatment of septic shock.Journal of intensive medicine · 2026Review
- Retinal Angiogenesis in Methamphetamine Self-Administration Rats.Investigative ophthalmology & visual science · 2025Article
- Acute Effects of Four Major Trace Amines on Zebrafish Behavioral, Neurochemical, and Neuroendocrine Responses.Journal of neurochemistry · 2025Article
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- Reappraisal of the mechanism of cardiovascular responses to sympathomimetic amines in anaesthetised rats: dual αNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Article
- A review of methamphetamine use and stroke in the young.Frontiers in neurology · 2024Review
- Consecutive treatments of methamphetamine promote the development of cardiac pathological symptoms in zebrafish.PloS one · 2023Article
- The trace amine theory of spontaneous hypertension as induced by classic monoamine oxidase inhibitors.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility.Nutrients · 2021Article
- Methamphetamine Use and Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2019Review
- Differential mechanisms of action of the trace amines octopamine, synephrine and tyramine on the porcine coronary and mesenteric artery.Scientific reports · 2019Article
- Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- The Case for TAAR1 as a Modulator of Central Nervous System Function.Frontiers in pharmacology · 2017Review
- Analgesic effects of β-phenylethylamine and various methylated derivatives in mice.Neurochemical research · 2014Article
- Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1.The Journal of pharmacology and experimental therapeutics · 2014Article
- Rat brain-uptake index for phenylethylamine and various monomethylated derivatives.Neurochemical research · 2013Article
- Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed.Vascular pharmacology · 2013Article
- Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.British journal of pharmacology · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trace amines including tyramine and β-phenylethylamine (β-PEA) increase blood pressure and cause vasoconstriction which is attributed to indirect sympathomimetic actions. However, there is evidence that they may also have non-sympathomimetic mechanisms. This study examined whether β-PEA causes vasoconstriction of rat aorta by a sympathomimetic action or through the recently described trace-amine-associated receptors (TAAR). Concentration-response curves (CRCs) for β-PEA were constructed either cumulatively or non-cumulatively in rat isolated aortic rings. TAAR-1 and TAAR-4 protein expression was determined in rat aorta by Western blotting and TAAR-1 mRNA by reverse transcriptase polymerase chain reaction (RT-PCR). β-PEA caused concentration-related constriction of rat aorta. The contractions were unaffected by endothelium removal or the nitric oxide synthase inhibitor, N(ω)-nitro-L-arginine methyl ester (L-NAME, 100 μM) or the cyclooxygenase inhibitor, indomethacin (10 μM). Non-cumulative CRCs showed greater contractions and sensitivity to β-PEA than cumulative. The α(1)-adrenoceptor antagonist, prazosin, failed to inhibit either curve. The β-adrenoceptor antagonist, propranolol, the adrenergic neuronal transport inhibitor, cocaine, and the monoamine oxidase inhibitor, pargyline, also failed to alter the CRC. In the combined presence of prazosin, cocaine, pargyline, and the selective β(2)-adrenoceptor antagonist, ICI-118,551, the trace amine contractile potency order was tryptamine > β-PEA > octopamine > D: -amphetamine > tyramine. Western blotting and RT-PCR revealed the presence of TAAR-1 in rat aorta, but TAAR-4 was poorly expressed. Vasoconstriction of rat aorta by β-PEA appears not to be an indirect sympathomimetic action. The presence of TAAR-1 suggests that vasoconstriction may be via these receptors; however, the potency order differed from that reported for transfected cells expressing rat TAAR-1.
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