ReviewPsychopharmacology2011
The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.
Review in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review.Developmental psychobiology · 2025Pooled it
- Maternal Stress and Maternal Microbiome Manipulations Remodel Offspring Medial Prefrontal Cortex in a Sex-Dependent Manner.Developmental neurobiology · 2025Article
- Early prenatal but not postnatal glucocorticoid exposure is associated with enhanced HPA axis activity into adulthood in a wild primate.Proceedings. Biological sciences · 2025Article
- Pregestational Prediabetes Induces Maternal Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation and Results in Adverse Foetal Outcomes.International journal of molecular sciences · 2024Article
- Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
- Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress.Frontiers in behavioral neuroscience · 2021Article
- Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.Human brain mapping · 2020Article
- mRNA and microRNA Profiles in the Amygdala Are Relevant to Susceptibility and Resilience to Psychological Stress Induced in Mice.Journal of molecular neuroscience : MN · 2020Article
- Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Prenatal cortisol modifies the association between maternal trauma history and child cognitive development in a sex-specific manner in an urban pregnancy cohort.Stress (Amsterdam, Netherlands) · 2019Article
- Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems?Toxicology · 2018Article
- Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together.Toxicology · 2018Article
- Perinatal stress and human hippocampal volume: Findings from typically developing young adults.Scientific reports · 2018Article
- Cortical control of object-specific grasp relies on adjustments of both activity and effective connectivity: a common marmoset study.The Journal of physiology · 2017Article
- Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.Zoological research · 2017Review
- Prenatal Maternal Stress and the Risk of Asthma in Children.Frontiers in pediatrics · 2017Review
- Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations.Brain sciences · 2016Review
- The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleExposure of the immature mammalian brain to stress factors, including stress levels of glucocorticoids, either prenatally or postnatally, is regarded as a major regulatory factor in short- and long-term brain function and, in human, as a major aetiological factor in neuropsychiatric disorders. Experimental human studies are not feasible and animal studies are required to demonstrate causality and elucidate mechanisms. A number of studies have been conducted and reviewed in rodents but there are relatively few studies in primates.
objectivesHere we present an overview of our published studies and some original data on the effects of: (1) prenatal stress on hypothalamic-pituitary-adrenal (HPA) re/activity and hippocampus neuroanatomy in juvenile-adolescent rhesus macaques; (2) prenatal dexamethasone (DEX) on HPA activity, behaviour and prefrontal cortex neuroanatomy in infant-adolescent common marmosets; (3) postnatal daily parental separation stress on HPA re/activity, behaviour, sleep and hippocampus and prefrontal cortex neuroanatomy in infant-adolescent common marmoset.
resultsPrenatal stress increased basal cortisol levels and reduced neurogenesis in macaque. Prenatal DEX was without effect on HPA activity and reduced social play and skilled motor behaviour in marmoset. Postnatal social stress increased basal cortisol levels, reduced social play, increased awakening and reduced hippocampal glucocorticoid and mineralocorticoid receptor expression in marmoset.
conclusionsPerinatal stress-related environmental events exert short- and long-term effects on HPA function, behaviour and brain status in rhesus macaque and common marmoset. The mechanisms mediating the enduring effects remain to be elucidated, with candidates including increased basal HPA function and epigenetic programming.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.