ArticleJournal of chemical ecology2010
Analysis of volatile organic compounds in human saliva by a static sorptive extraction method and gas chromatography-mass spectrometry.
Article in Journal of chemical ecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 97 citations in OpenAlex.
- Comprehensive GC/MS Profiling of Volatile Organic Compounds in Whole and Glandular Saliva Using MonoTrap Micro-Extraction.Metabolites · 2025Article
- Exploring exhaled breath biomarkers for lactose intolerance diagnosis: the Lactobreath pilot study protocol.BMJ open · 2025Article
- The human volatilome meets cancer diagnostics: past, present, and future of noninvasive applications.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Computational and experimental microfluidics: Total analysis system for mixing, sorting, and concentrating particles and cells.APL bioengineering · 2024Article
- To metabolomics and beyond: a technological portfolio to investigate cancer metabolism.Signal transduction and targeted therapy · 2023Review
- Review
- Development of a safety protocol for training and using SARS-CoV-2 detection dogs: A pilot study.Journal of veterinary behavior : clinical applications and research : official journal of : Australian Veterinary Behaviour Interest Group, International Working Dog Breeding Association · 2023Article
- A cerumenolomic approach to bovine trypanosomosis diagnosis.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Expert considerations and consensus for using dogs to detect human SARS-CoV-2-infections.Frontiers in medicine · 2022Article
- A clinical nomogram incorporating salivaryAnnals of translational medicine · 2021Article
- Recent Metabolomics Analysis in Tumor Metabolism Reprogramming.Frontiers in molecular biosciences · 2021Review
- Metabolomics of Oral/Head and Neck Cancer.Advances in experimental medicine and biology · 2021Article
- Article
- Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection.Journal of extracellular vesicles · 2020Article
- Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review.Molecules (Basel, Switzerland) · 2020Review
- Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.Human molecular genetics · 2020Article
- Monitoring of Bactericidal Effects of Silver Nanoparticles Based on Protein Signatures and VOC Emissions fromJournal of clinical medicine · 2019Article
- Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study.Iranian journal of basic medical sciences · 2019Article
- Cerumenogram: a new frontier in cancer diagnosis in humans.Scientific reports · 2019Article
- Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.ACS central science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human saliva not only helps control oral health (with anti-microbial proteins), but it may also play a role in chemical communication. As is the case with other mammalian species, human saliva contains peptides, proteins, and numerous volatile organic compounds (VOCs). A high-throughput analytical method is described for profiling a large number of saliva samples to screen the profiles of VOCs. Saliva samples were collected in a non-stimulated fashion. The method utilized static stir bar extraction followed by gas chromatography-mass spectrometry (GC-MS). The method provided excellent reproducibility for a wide range of salivary compounds, including alcohols, aldehydes, ketones, carboxylic acids, esters, amines, amides, lactones, and hydrocarbons. Furthermore, substantial overlap of salivary VOCs and the previously reported skin VOCs in the same subject group was found in this study by using pattern recognition analyses. Sensitivity, precision, and reproducibility of the method suggest that this technique has potential in physiological, metabolomic, pharmacokinetic, forensic, and toxicological studies of small organic compounds where a large number of human saliva samples are involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.