ArticleMolecular medicine (Cambridge, Mass.)
A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Strength training and aerobic exercise training for muscle disease.The Cochrane database of systematic reviews · 2019Pooled it
- Physical therapy in adult inflammatory myopathy patients: a systematic review.Clinical rheumatology · 2019Pooled it
- Trial
- The effects of resistance training in patients with primary Sjogren's syndrome.Clinical rheumatology · 2022Trial
- The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training.Arthritis research & therapy · 2019Trial
- Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study.PloS one · 2017Trial
- Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis.Arthritis research & therapy · 2013Trial
- High-load resistance training and FSHD: harmful mixture or a silver bullet combination?Journal of neurology · 2026Review
- Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD.The Journal of physiology · 2025Article
- Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms.Frontiers in endocrinology · 2025Review
- Saturation effects of the relationship between physical exercise and systemic immune inflammation index in the short-sleep population: a cross-sectional study.BMC public health · 2024Article
- The Role of Exercise to Improve Physiological, Physical and Psychological Health Outcome in Idiopathic Inflammatory Myopathies (IIM).Journal of inflammation research · 2024Review
- Urine proteomics by mass spectrometry identifies proteins involved in key pathogenic pathways in patients with juvenile dermatomyositis.Rheumatology (Oxford, England) · 2023Article
- The molecular mechanism underlying dermatomyositis related interstitial lung disease: evidence from bioinformatic analysis andFrontiers in immunology · 2023Article
- Harnessing the benefits of yoga for myositis, muscle dystrophies, and other musculoskeletal disorders.Clinical rheumatology · 2022Review
- Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training.Arthritis research & therapy · 2022Article
- High-intensity strength training in patients with idiopathic inflammatory myopathies: a randomised controlled trial protocol.BMJ open · 2021Article
- Exercise in Myositis.Current treatment options in rheumatology · 2018Review
- Physical activity for paediatric rheumatic diseases: standing up against old paradigms.Nature reviews. Rheumatology · 2017Review
- Selected aspects of the current management of myositis.Therapeutic advances in musculoskeletal disease · 2016Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Polymyositis and dermatomyositis are orphan, chronic skeletal muscle disorders characterized by weakness, infiltrations by mononuclear inflammatory cells, and fibrosis. Until recently, patients were advised to refrain from physical activity because of fears of exacerbation of muscle inflammation. However, recent studies have shown that moderate exercise training in combination with immunosuppressive drugs can improve muscle performance. Despite the positive effects of exercise training, the molecular mechanisms underlying the exercise-associated clinical improvements remain poorly understood. The present study was designed to define, at the molecular level, the effects of resistance exercise training on muscle performance and disease progression in myositis patients. We evaluated changes in muscle strength, histology and genome-wide mRNA profiles to determine the beneficial effects of exercise and determine the possible molecular changes associated with improved muscle performance. A total of 8 myositis patients underwent a 7-wk resistance exercise training program that resulted in improved muscle strength and increased maximal oxygen uptake (VO(2max)). Training also resulted in marked reductions in gene expression, reflecting reductions in proinflammatory and profibrotic gene networks, changes that were also accompanied by a reduction in tissue fibrosis. Consistent with the exercise-associated increase in VO(2max), a subset of transcripts was associated with a shift toward oxidative metabolism. The changes in gene expression reported in the present study are in agreement with the performance improvements induced by exercise and suggest that resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.