ArticlePLoS computational biology2010
Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Twists and turns: 40 years of investigating how and why bacteria swim.Microbiology (Reading, England) · 2024Review
- Article
- Azorhizobium caulinodans Chemotaxis Is Controlled by an Unusual Phosphorelay Network.Journal of bacteriology · 2022Article
- Maximization of information transmission influences selection of native phosphorelay architectures.PeerJ · 2021Article
- Article
- Article
- A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides (†).Interface focus · 2014Article
- Phosphate sink containing two-component signaling systems as tunable threshold devices.PLoS computational biology · 2014Article
- Functional organization of a multimodular bacterial chemosensory apparatus.PLoS genetics · 2014Article
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Response kinetics in the complex chemotaxis signalling pathway of Rhodobacter sphaeroides.Journal of the Royal Society, Interface · 2013Article
- Transient dynamic phenotypes as criteria for model discrimination: fold-change detection in Rhodobacter sphaeroides chemotaxis.Journal of the Royal Society, Interface · 2013Article
- Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks.PLoS computational biology · 2013Article
- The Azospirillum brasilense Che1 chemotaxis pathway controls swimming velocity, which affects transient cell-to-cell clumping.Journal of bacteriology · 2012Article
- Genome sequence of Rhodobacter sphaeroides Strain WS8N.Journal of bacteriology · 2011Article
- Signal processing in complex chemotaxis pathways.Nature reviews. Microbiology · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and response regulators (RRs). These are used to sense and respond to changes in the environment. Rhodobacter sphaeroides has a complex chemosensory network with two signaling clusters, each containing a HPK, CheA. Here we demonstrate, using a mathematical model, how the outputs of the two signaling clusters may be integrated. We use our mathematical model supported by experimental data to predict that: (1) the main RR controlling flagellar rotation, CheY(6), aided by its specific phosphatase, the bifunctional kinase CheA(3), acts as a phosphate sink for the other RRs; and (2) a phosphorelay pathway involving CheB(2) connects the cytoplasmic cluster kinase CheA(3) with the polar localised kinase CheA(2), and allows CheA(3)-P to phosphorylate non-cognate chemotaxis RRs. These two mechanisms enable the bifunctional kinase/phosphatase activity of CheA(3) to integrate and tune the sensory output of each signaling cluster to produce a balanced response. The signal integration mechanisms identified here may be widely used by other bacteria, since like R. sphaeroides, over 50% of chemotactic bacteria have multiple cheA homologues and need to integrate signals from different sources.
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Registered trials
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