ArticlePloS one2010
Estimating the accuracy of anal cytology in the presence of an imperfect reference standard.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Pooled it
- Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.Cancer cytopathology · 2019Trial
- Natural history of anal dysplasia in an HIV-infected clinical care cohort: estimates using multi-state Markov modeling.PloS one · 2014Trial
- Strengthening anal cancer prevention in people with HIV without immediate HRA access-correspondence.Annals of medicine and surgery (2012) · 2025Article
- Shared Decision-Making Concerning Anal Cancer Screening in Persons With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Comparative diagnostic accuracy studies with an imperfect reference standard - a comparison of correction methods.BMC medical research methodology · 2021Article
- 5-Year Prospective Evaluation of Cytology, Human Papillomavirus Testing, and Biomarkers for Detection of Anal Precancer in Human Immunodeficiency Virus-Positive Men Who Have Sex With Men.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Human Papillomavirus-16 DNA Quantitation Differentiates High-Grade Anal Neoplasia.International journal of environmental research and public health · 2018Article
- Disparities in the Clinical Evolution of Anal Neoplasia in an HIV-Infected Cohort.Journal of racial and ethnic health disparities · 2018Article
- Effects of Referral Bias on Estimates of Anal Intraepithelial Neoplasia Progression and Regression Rates in a 3-State Markov Model.Medicine · 2015Article
- Screening for Anal Cancer in Women.Journal of lower genital tract disease · 2015Review
- Five-year cumulative incidence of invasive anal cancer among HIV-infected patients according to baseline anal cytology results: an inception cohort analysis.HIV medicine · 2015Article
- HPV and anal cancer in HIV-infected individuals: a review.Current HIV/AIDS reports · 2014Review
- A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with men.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Assessing diagnostic tests: how to correct for the combined effects of interpretation and reference standard.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe study aim is to estimate sensitivity and specificity of anal cytology for histologic HSIL in analyses adjusted for the imperfect biopsy reference standard. METHODS AND PRINCIPAL
findingsRetrospective cohort study of an anal dysplasia screening program for HIV infected adults. We estimated the prevalence of histologic HSIL by concurrent cytology category and the associated cytology ROC area. Cytology operating characteristics for HSIL were estimated and adjusted for the imperfect reference standard by 3 methodologies. The study cohort included 261 patients with 3 available measures: (1) referral cytology; (2) HRA cytology; and (3) HRA directed biopsy. The prevalence of biopsy HSIL varied according to the concurrent HRA cytology result: 64.5% for HSIL or ASC-H, 12.6% for LSIL, 10.9% for ASCUS, and 6.3% for no abnormality. The cytology ROC area was 0.78. The observed prevalence of HSIL was 37% (referral cytology), 24% (HRA cytology), and 24% (HRA biopsy). Unadjusted estimates of sensitivity and specificity of cytology were 0.66 and 0.90, respectively. Adjusted estimates varied from 0.47-0.89 (sensitivity) and 0.89-1.0 (specificity).
conclusionsAnalysis of a single dataset yields widely different estimates of anal cytology operating characteristics that depend on difficult to verify assumptions regarding the accuracy of the imperfect reference standard.
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