ArticlePloS one2010
Competing activities of heterotrimeric G proteins in Drosophila wing maturation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
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- Restoration of the GTPase activity and cellular interactions of GαScience advances · 2022Article
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- Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 ofCells · 2021Article
- Subtype-dependent regulation of Gβγ signalling.Cellular signalling · 2021Review
- Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival inMolecules and cells · 2021Article
- Antagonistic PCP Signaling Pathways in the developing Drosophila eye.Scientific reports · 2018Article
- Outside-in signaling--a brief review of GPCR signaling with a focus on the Drosophila GPCR family.Journal of cell science · 2015Review
- Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.Development (Cambridge, England) · 2014Article
- Role of Go/i subgroup of G proteins in olfactory signaling of Drosophila melanogaster.The European journal of neuroscience · 2014Article
- The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons.Journal of neurophysiology · 2014Article
- Article
- Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.Cell host & microbe · 2013Article
- Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.PloS one · 2013Article
- Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Deconstructing host-pathogen interactions in Drosophila.Disease models & mechanisms · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the pupal wing into the firm adult flight organ. Here we show that another alpha-subunit Galphao can specifically antagonize the Galphas activities by competing for the Gbeta13F/Ggamma1 subunits of the heterotrimeric Gs protein complex. Loss of Gbeta13F, Ggamma1, or Galphas, but not any other G protein subunit, results in prevention of post-eclosion cell death and failure of the wing expansion. However, cell death prevention alone is not sufficient to induce the expansion defect, suggesting that the failure of epithelial-mesenchymal transition is key to the folded wing phenotypes. Overactivation of Galphas with cholera toxin mimics expression of constitutively activated Galphas and promotes wing blistering due to precocious cell death. In contrast, co-overexpression of Gbeta13F and Ggamma1 does not produce wing blistering, revealing the passive role of the Gbetagamma in the Galphas-mediated activation of apoptosis, but hinting at the possible function of Gbetagamma in the epithelial-mesenchymal transition. Our results provide a comprehensive functional analysis of the heterotrimeric G protein proteome in the late stages of Drosophila wing development.
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