ArticlePloS one2010
Leftward lateralization of auditory cortex underlies holistic sound perception in Williams syndrome.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Chronology of auditory processing and related co-activation in the orbitofrontal cortex depends on musical expertise.Frontiers in neuroscience · 2022Article
- Different Frequency of Heschl's Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders.Frontiers in human neuroscience · 2022Article
- Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.Frontiers in aging neuroscience · 2022Article
- Review
- Music Affinity and Emotion in Williams Syndrome.Music and medicine · 2020Article
- TASH: Toolbox for the Automated Segmentation of Heschl's gyrus.Scientific reports · 2020Article
- Reduced cortical thickness in Heschl's gyrus as an in vivo marker for human primary auditory cortex.Human brain mapping · 2019Article
- Dental-craniofacial manifestation and treatment of rare diseases.International journal of oral science · 2019Review
- Auditory Cortex Morphology Predicts Language Learning Potential in Children and Teenagers.Frontiers in neuroscience · 2019Article
- Williams Syndrome and Music: A Systematic Integrative Review.Frontiers in psychology · 2018Article
- "When Music Speaks": Auditory Cortex Morphology as a Neuroanatomical Marker of Language Aptitude and Musicality.Frontiers in psychology · 2017Article
- Neural Biomarkers for Dyslexia, ADHD, and ADD in the Auditory Cortex of Children.Frontiers in neuroscience · 2016Article
- Beat Perception and Sociability: Evidence from Williams Syndrome.Frontiers in psychology · 2016Article
- Neural correlates of amusia in williams syndrome.Brain sciences · 2014Article
- Size and synchronization of auditory cortex promotes musical, literacy, and attentional skills in children.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Moderating variables of music training-induced neuroplasticity: a review and discussion.Frontiers in psychology · 2013Review
- (A)musicality in Williams syndrome: examining relationships among auditory perception, musical skill, and emotional responsiveness to music.Frontiers in psychology · 2013Article
- The effect of intellectual ability on functional activation in a neurodevelopmental disorder: preliminary evidence from multiple fMRI studies in Williams syndrome.Journal of neurodevelopmental disorders · 2012Article
- Human primary auditory cortex follows the shape of Heschl's gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with the rare genetic disorder Williams-Beuren syndrome (WS) are known for their characteristic auditory phenotype including strong affinity to music and sounds. In this work we attempted to pinpoint a neural substrate for the characteristic musicality in WS individuals by studying the structure-function relationship of their auditory cortex. Since WS subjects had only minor musical training due to psychomotor constraints we hypothesized that any changes compared to the control group would reflect the contribution of genetic factors to auditory processing and musicality. METHODOLOGY/PRINCIPAL
findingsUsing psychoacoustics, magnetoencephalography and magnetic resonance imaging, we show that WS individuals exhibit extreme and almost exclusive holistic sound perception, which stands in marked contrast to the even distribution of this trait in the general population. Functionally, this was reflected by increased amplitudes of left auditory evoked fields. On the structural level, volume of the left auditory cortex was 2.2-fold increased in WS subjects as compared to control subjects. Equivalent volumes of the auditory cortex have been previously reported for professional musicians. CONCLUSIONS/SIGNIFICANCE: There has been an ongoing debate in the neuroscience community as to whether increased gray matter of the auditory cortex in musicians is attributable to the amount of training or innate disposition. In this study musical education of WS subjects was negligible and control subjects were carefully matched for this parameter. Therefore our results not only unravel the neural substrate for this particular auditory phenotype, but in addition propose WS as a unique genetic model for training-independent auditory system properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.