ArticlePloS one2010
Soft matrices suppress cooperative behaviors among receptor-ligand bonds in cell adhesion.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A multi-scale clutch model for adhesion complex mechanics.PLoS computational biology · 2023Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures.Nature communications · 2018Article
- The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate.Membranes · 2017Article
- Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM.Biophysical journal · 2017Article
- Integrin-mediated mechanotransduction.The Journal of cell biology · 2016Review
- A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion.Royal Society open science · 2016Article
- Effects of surface viscoelasticity on cellular responses of endothelial cells.Reports of biochemistry & molecular biology · 2014Article
- USNCTAM perspectives on mechanics in medicine.Journal of the Royal Society, Interface · 2014Article
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- Effect of viscous drag on multiple receptor-ligand bonds rupture force.Colloids and surfaces. B, Biointerfaces · 2012Article
- Effect of loading conditions on the dissociation behaviour of catch bond clusters.Journal of the Royal Society, Interface · 2012Article
- Relationship between cell compatibility and elastic modulus of silicone rubber/organoclay nanobiocomposites.Jundishapur journal of natural pharmaceutical products · 2012Article
- Bond energy effects on strength, cooperativity and robustness of molecular structures.Interface focus · 2011Article
- Probing mechanical principles of focal contacts in cell-matrix adhesion with a coupled stochastic-elastic modelling framework.Journal of the Royal Society, Interface · 2011Review
- Motor force homeostasis in skeletal muscle contraction.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed bonds (death rate) and the rate of rebinding of open bonds (birth rate) in a bond cluster. We have recently shown that soft matrices can greatly increase the death rate in a bond cluster by inducing severe stress concentration near the adhesion edges. In the present paper, we report a more striking effect that, irrespective of stress concentration, soft matrices also suppress the birth rate in a bond cluster by increasing the local separation distance between open bonds. This is shown by theoretical analysis as well as Monte Carlo simulations based on a stochastic-elasticity model in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial force/separation are unified in a single modeling framework. Our findings not only are important for understanding the role of elastic matrices in cell adhesion, but also have general implications on adhesion between soft materials.
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