ArticleMolecular vision2010
Light-dependant intraretinal ion regulation by melanopsin in young awake and free moving mice evaluated with manganese-enhanced MRI.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Lifelong Changes in the Choroidal Thickness, Refractive Status, and Ocular Dimensions in C57BL/6J Mouse.Investigative ophthalmology & visual science · 2024Article
- Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.Investigative ophthalmology & visual science · 2021Article
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.NMR in biomedicine · 2018Article
- Melanopsin Phototransduction Contributes to Light-Evoked Choroidal Expansion and Rod L-Type Calcium Channel Function In Vivo.Investigative ophthalmology & visual science · 2016Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- MRI of Retinal Free Radical Production With Laminar Resolution In Vivo.Investigative ophthalmology & visual science · 2016Article
- Photoreceptors in diabetic retinopathy.Journal of diabetes investigation · 2015Review
- Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.Investigative ophthalmology & visual science · 2015Article
- Development of an MRI biomarker sensitive to tetrameric visual arrestin 1 and its reduction via light-evoked translocation in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy.Investigative ophthalmology & visual science · 2015Article
- MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy.Expert opinion on medical diagnostics · 2013Review
- Evidence for diffuse central retinal edema in vivo in diabetic male Sprague Dawley rats.PloS one · 2012Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
- Same-session functional assessment of rat retina and brain with manganese-enhanced MRI.NeuroImage · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo test the hypothesis that in young, functionally blind mice, light-dependent intraretinal ion regulation occurs via melanopsin.
methodsPostnatal day (P) 7 wild type (WT, C57Bl/6) and melanopsin knockout (KO, opn4-/-, B6129) mice were light or dark adapted. Awake and freely moving animals were injected intraperitoneally (ip) with MnCl(2). Four hours later, the mice in both groups were anesthetized and studied with manganese-enhanced MRI (MEMRI) to measure the extent of intraretinal uptake of manganese and whole retinal thicknesses.
resultsIn control P7 mice, light exposure increased (p<0.05) retinal manganese uptake over that in dark. This difference was observed throughout most of the retina. In P7 KO mice, intraretinal manganese uptake did not differ from that in age-matched dark-adapted WT mice, and was not light-dependent. No differences in whole retinal thickness were noted between groups.
conclusionsFirst time evidence is presented which demonstrates intraretinal ion regulation by melanopsin in vivo.
Indexed as
Identifiers
20808732PMC2929942W165731464What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.