ArticleCurrent neuropharmacology2010
Past, present and future therapeutics for cerebellar ataxias.
Article in Current neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Anodal Cerebellar Transcranial Direct Current Stimulation on Movements in Patients with Cerebellar Ataxias: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- First Application of a Novel Brain Template: Motor Training Improves Cortico-cerebellar Connectivity in Cerebellar Ataxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Adipose tissue-derived mesenchymal stem cells have better restorative capacity than bone marrow-derived cells in a cerebellar ataxic rat model.Archives of medical science : AMS · 2025Article
- Post-symptomatic administration of hMSCs exerts therapeutic effects in SCA2 mice.Stem cell research & therapy · 2024Article
- Effects of cerebellar transcranial alternating current stimulation in cerebellar ataxia: study protocol for a randomised controlled trial.Frontiers in neuroscience · 2023Article
- Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation.Journal of clinical medicine · 2020Article
- TGF-β1 Provides Neuroprotection via Inhibition of Microglial Activation in 3-Acetylpyridine-Induced Cerebellar Ataxia Model Rats.Frontiers in neuroscience · 2020Article
- D3T acts as a pro-oxidant in a cell culture model of diabetes-induced peripheral neuropathy.Redox biology · 2019Article
- Liver Growth Factor (LGF) Upregulates Frataxin Protein Expression and Reduces Oxidative Stress in Friedreich's Ataxia Transgenic Mice.International journal of molecular sciences · 2016Article
- Landmark Based Shape Analysis for Cerebellar Ataxia Classification and Cerebellar Atrophy Pattern Visualization.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Experimental neurotransplantation treatment for hereditary cerebellar ataxias.Cerebellum & ataxias · 2016Review
- Single session imaging of cerebellum at 7 Tesla: obtaining structure and function of multiple motor subsystems in individual subjects.PloS one · 2015Article
- Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.Genes · 2014Article
- Neuroprotective role of liver growth factor "LGF" in an experimental model of cerebellar ataxia.International journal of molecular sciences · 2014Article
- Liver growth factor as a tissue regenerating factor in neurodegenerative diseases.Recent patents on CNS drug discovery · 2014Review
- Cellular commitment in the developing cerebellum.Frontiers in cellular neuroscience · 2014Review
- Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases.The Journal of biological chemistry · 2013Article
- Intracerebellar application of P19-derived neuroprogenitor and naive stem cells to Lurcher mutant and wild type B6CBA mice.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Effects of intravenous administration of human umbilical cord blood stem cells in 3-acetylpyridine-lesioned rats.Stem cells international · 2012Article
- Anticipation strategies of motor control in children and adolescents with cerebellar pathologies and typical development: a dual task paradigm.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar ataxias are a group of disabling neurological disorders. Patients exhibit a cerebellar syndrome and can also present with extra-cerebellar deficits, namely pigmentary retinopathy, extrapyramidal movement disorders, pyramidal signs, cortical symptoms (seizures, cognitive impairment/behavioural symptoms), and peripheral neuropathy. Recently, deficits in cognitive operations have been unraveled. Cerebellar ataxias are heterogeneous both at the phenotypic and genotypic point of view. Therapeutical trials performed during these last 4 decades have failed in most cases, in particular because drugs were not targeting a deleterious pathway, but were given to counteract putative defects in neurotransmission. The identification of the causative mutations of many hereditary ataxias, the development of relevant animal models and the recent identifications of the molecular mechanisms underlying ataxias are impacting on the development of new drugs. We provide an overview of the pharmacological treatments currently used in the clinical practice and we discuss the drugs under development.
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