ArticlePloS one2010
Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Organophosphate-Pesticide-Mediated Immune Response Modulation in Invertebrates and Vertebrates.International journal of molecular sciences · 2023Review
- Effects of Pesticides on Longevity and Bioenergetics in Invertebrates-The Impact of Polyphenolic Metabolites.International journal of molecular sciences · 2021Article
- Xenobiotic metabolism and transport inJournal of toxicology and environmental health. Part B, Critical reviews · 2021Review
- Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function.Toxicology reports · 2021Article
- Neonicotinoid-containing insecticide disruption of growth, locomotion, and fertility in Caenorhabditis elegans.PloS one · 2020Article
- Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression-A Mouse Study.International journal of molecular sciences · 2017Article
- The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2017Review
- Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2016Article
- Fluorescence spectroscopy approaches for the development of a real-time organophosphate detection system using an enzymatic sensor.Sensors (Basel, Switzerland) · 2015Article
- Systems level analysis and identification of pathways and networks associated with liver fibrosis.PloS one · 2014Article
- Article
- Bioactivity of nanosilver inToxicology reports · 2014Article
- Determination of reliable reference genes for multi-generational gene expression analysis on C. elegans exposed to abused drug nicotine.Psychopharmacology · 2013Article
- Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX.Neurochemical research · 2013Article
- Assessing the detection capacity of microarrays as bio/nanosensing platforms.BioMed research international · 2013Article
- Article
- Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils.Ecotoxicology (London, England) · 2013Article
- Analyzing the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays.Cancer cell international · 2012Article
- Aging Uncouples Heritability and Expression-QTL in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Determining genetic expression profiles in C. elegans using microarray and real-time PCR.Journal of visualized experiments : JoVE · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is known, however, about gene expression responses against OPs in the nematode Caenorhabditis elegans. This is surprising because C. elegans is extensively used as a model species in toxicity studies. To address this question we performed a microarray study in C. elegans which was exposed for 72 hrs to two widely used Ops, chlorpyrifos and diazinon, and a low dose mixture of these two compounds. Our analysis revealed transcriptional responses related to detoxification, stress, innate immunity, and transport and metabolism of lipids in all treatments. We found that for both compounds as well as in the mixture, these processes were regulated by different gene transcripts. Our results illustrate intense, and unexpected crosstalk between gene pathways in response to chlorpyrifos and diazinon in C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.