ReviewNature reviews. Clinical oncology2010
The role of radiotherapy for metastatic epidural spinal cord compression.
Review in Nature reviews. Clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Prognostic factors in patients with metastatic spinal cord compression secondary to lung cancer: a systematic review of the literature.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Pooled it
- Evidence-based management of metastatic spinal cord compression (MSCC): expert recommendations for standardizing care in Spain.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Advances and Future Perspectives for the Management of Non-Small Cell Lung Cancer in Australia: A Narrative Review.Asia-Pacific journal of clinical oncology · 2026Review
- Article
- Integrated management of metastatic spinal tumors: current status and future directions.Medical oncology (Northwood, London, England) · 2025Review
- Analysis of Early Post-Radiation Surgical Management of Metastatic Spinal Tumors.Journal of clinical medicine · 2025Article
- Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors.Cancer science · 2024Article
- The Lancet Commission on prostate cancer: planning for the surge in cases.Lancet (London, England) · 2024Review
- Incidence and radiotherapy treatment patterns of complicated bone metastases.Journal of bone oncology · 2024Article
- QL1604 combined with bevacizumab as an innovative first-line treatment for HCC patient with extensive metastasis who showed remarkable effect: a case report.Frontiers in pharmacology · 2024Article
- Factors affecting survival and prognosis in surgically treated patients with spinal metastases arising from renal cell carcinoma.BMC urology · 2023Article
- The impact of radiosensitivity on clinical outcomes of spinal metastases treated with stereotactic body radiotherapy.Cancer medicine · 2023Article
- Risk of Myelopathy Following Second Local Treatment after Initial Irradiation of Spine Metastasis.Diagnostics (Basel, Switzerland) · 2023Review
- Common oncologic emergencies.Canadian family physician Medecin de famille canadien · 2023Article
- Incidence and risk factors associated with the development of metastatic spinal cord compression due to bone metastasis in women with cervical cancer.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- A New Clinical Instrument for Estimating the Ambulatory Status after Irradiation for Malignant Spinal Cord Compression.Cancers · 2022Article
- Stereotactic body radiotherapy for spinal metastases: a review.Medical oncology (Northwood, London, England) · 2022Review
- Article
- Article
- Electron beam intraoperative radiotherapy for metastatic epidural spinal cord compression: a prospective observational study.Clinical & experimental metastasis · 2021Observational
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy alone is the most common treatment for metastatic epidural spinal cord compression (MESCC). Decompressive surgery followed by radiotherapy is generally indicated only in 10-15% of MESCC cases. Chemotherapy has an unclear role and may be considered for selected patients with hematological or germ-cell malignancies. If radiotherapy alone is given, it is important to select the appropriate regimen. Similar functional outcomes can be achieved with short-course radiotherapy regimens and longer-course radiotherapy regimens. Longer-course radiotherapy is associated with better local control of MESCC than short-course radiotherapy. Patients with a more favorable survival prognosis (expected survival of ≥6 months) should receive longer-course radiotherapy, as they may live long enough to develop a recurrence of MESCC. Patients with an expected survival of <6 months should be considered for short-course radiotherapy. A recurrence of MESCC in the previously irradiated region after short-course radiotherapy may be treated with another short-course of radiotherapy. After primary administration of longer-course radiotherapy, decompressive surgery should be performed if indicated. Alternatively, re-irradiation can be performed using high-precision techniques to reduce the cumulative dose received by the spinal cord. Larger prospective trials are required to better define the appropriate treatment for the individual patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.